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Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.
Varticovski L, Hollingshead MG, Robles AI, Wu X, Cherry J, Munroe DJ, Lukes L, Anver MR, Carter JP, Borgel SD, Stotler H, Bonomi CA, Nunez NP, Hursting SD, Qiao W, Deng CX, Green JE, Hunter KW, Merlino G, Steeg PS, Wakefield LM, Barrett JC. Varticovski L, et al. Among authors: deng cx. Clin Cancer Res. 2007 Apr 1;13(7):2168-77. doi: 10.1158/1078-0432.CCR-06-0918. Clin Cancer Res. 2007. PMID: 17404101
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.
Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D. Kim HS, et al. Among authors: deng cx. Cancer Cell. 2010 Jan 19;17(1):41-52. doi: 10.1016/j.ccr.2009.11.023. Cancer Cell. 2010. PMID: 20129246 Free PMC article.
BRCA1 affects global DNA methylation through regulation of DNMT1.
Shukla V, Coumoul X, Lahusen T, Wang RH, Xu X, Vassilopoulos A, Xiao C, Lee MH, Man YG, Ouchi M, Ouchi T, Deng CX. Shukla V, et al. Among authors: deng cx. Cell Res. 2010 Nov;20(11):1201-15. doi: 10.1038/cr.2010.128. Epub 2010 Sep 7. Cell Res. 2010. PMID: 20820192 Free PMC article.
413 results