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Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway.
John M, Constien R, Akinc A, Goldberg M, Moon YA, Spranger M, Hadwiger P, Soutschek J, Vornlocher HP, Manoharan M, Stoffel M, Langer R, Anderson DG, Horton JD, Koteliansky V, Bumcrot D. John M, et al. Among authors: goldberg m. Nature. 2007 Oct 11;449(7163):745-7. doi: 10.1038/nature06179. Epub 2007 Sep 26. Nature. 2007. PMID: 17898712 Free PMC article.
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.
Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, Bacallado SA, Nguyen DN, Fuller J, Alvarez R, Borodovsky A, Borland T, Constien R, de Fougerolles A, Dorkin JR, Narayanannair Jayaprakash K, Jayaraman M, John M, Koteliansky V, Manoharan M, Nechev L, Qin J, Racie T, Raitcheva D, Rajeev KG, Sah DW, Soutschek J, Toudjarska I, Vornlocher HP, Zimmermann TS, Langer R, Anderson DG. Akinc A, et al. Among authors: goldberg m. Nat Biotechnol. 2008 May;26(5):561-9. doi: 10.1038/nbt1402. Epub 2008 Apr 27. Nat Biotechnol. 2008. PMID: 18438401 Free PMC article.
Development of lipidoid-siRNA formulations for systemic delivery to the liver.
Akinc A, Goldberg M, Qin J, Dorkin JR, Gamba-Vitalo C, Maier M, Jayaprakash KN, Jayaraman M, Rajeev KG, Manoharan M, Koteliansky V, Röhl I, Leshchiner ES, Langer R, Anderson DG. Akinc A, et al. Among authors: goldberg m. Mol Ther. 2009 May;17(5):872-9. doi: 10.1038/mt.2009.36. Epub 2009 Mar 3. Mol Ther. 2009. PMID: 19259063 Free PMC article.
Assessing siRNA pharmacodynamics in a luciferase-expressing mouse.
Svensson RU, Shey MR, Ballas ZK, Dorkin JR, Goldberg M, Akinc A, Langer R, Anderson DG, Bumcrot D, Henry MD. Svensson RU, et al. Among authors: goldberg m. Mol Ther. 2008 Dec;16(12):1995-2001. doi: 10.1038/mt.2008.187. Epub 2008 Sep 9. Mol Ther. 2008. PMID: 18781145 Free PMC article.
Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis.
Huang YH, Bao Y, Peng W, Goldberg M, Love K, Bumcrot DA, Cole G, Langer R, Anderson DG, Sawicki JA. Huang YH, et al. Among authors: goldberg m. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3426-30. doi: 10.1073/pnas.0813348106. Epub 2009 Feb 10. Proc Natl Acad Sci U S A. 2009. PMID: 19208807 Free PMC article.
Drug delivery-mediated control of RNA immunostimulation.
Nguyen DN, Chen SC, Lu J, Goldberg M, Kim P, Sprague A, Novobrantseva T, Sherman J, Shulga-Morskaya S, de Fougerolles A, Chen J, Langer R, Anderson DG. Nguyen DN, et al. Among authors: goldberg m. Mol Ther. 2009 Sep;17(9):1555-62. doi: 10.1038/mt.2009.147. Epub 2009 Jul 7. Mol Ther. 2009. PMID: 19584813 Free PMC article.
4,450 results