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Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
Krug A, Towarowski A, Britsch S, Rothenfusser S, Hornung V, Bals R, Giese T, Engelmann H, Endres S, Krieg AM, Hartmann G. Krug A, et al. Among authors: hornung v. Eur J Immunol. 2001 Oct;31(10):3026-37. doi: 10.1002/1521-4141(2001010)31:10<3026::aid-immu3026>3.0.co;2-h. Eur J Immunol. 2001. PMID: 11592079 Free article.
Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells.
Kerkmann M, Costa LT, Richter C, Rothenfusser S, Battiany J, Hornung V, Johnson J, Englert S, Ketterer T, Heckl W, Thalhammer S, Endres S, Hartmann G. Kerkmann M, et al. Among authors: hornung v. J Biol Chem. 2005 Mar 4;280(9):8086-93. doi: 10.1074/jbc.M410868200. Epub 2004 Dec 8. J Biol Chem. 2005. PMID: 15591070 Free article.
221 results