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A versatile bifunctional chelate for radiolabeling humanized anti-CEA antibody with In-111 and Cu-64 at either thiol or amino groups: PET imaging of CEA-positive tumors with whole antibodies.
Li L, Bading J, Yazaki PJ, Ahuja AH, Crow D, Colcher D, Williams LE, Wong JY, Raubitschek A, Shively JE. Li L, et al. Among authors: raubitschek a. Bioconjug Chem. 2008 Jan;19(1):89-96. doi: 10.1021/bc700161p. Epub 2007 Nov 8. Bioconjug Chem. 2008. PMID: 17988078 Free PMC article.
Monodispersed DOTA-PEG-conjugated anti-TAG-72 diabody has low kidney uptake and high tumor-to-blood ratios resulting in improved 64Cu PET.
Li L, Turatti F, Crow D, Bading JR, Anderson AL, Poku E, Yazaki PJ, Williams LE, Tamvakis D, Sanders P, Leong D, Raubitschek A, Hudson PJ, Colcher D, Shively JE. Li L, et al. Among authors: raubitschek a. J Nucl Med. 2010 Jul;51(7):1139-46. doi: 10.2967/jnumed.109.074153. Epub 2010 Jun 16. J Nucl Med. 2010. PMID: 20554731 Free PMC article.
A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance.
Yazaki PJ, Lee B, Channappa D, Cheung CW, Crow D, Chea J, Poku E, Li L, Andersen JT, Sandlie I, Orcutt KD, Wittrup KD, Shively JE, Raubitschek A, Colcher D. Yazaki PJ, et al. Among authors: raubitschek a. Protein Eng Des Sel. 2013 Mar;26(3):187-93. doi: 10.1093/protein/gzs096. Epub 2012 Nov 21. Protein Eng Des Sel. 2013. PMID: 23175797 Free PMC article.
Humanization of the anti-CEA T84.66 antibody based on crystal structure data.
Yazaki PJ, Sherman MA, Shively JE, Ikle D, Williams LE, Wong JY, Colcher D, Wu AM, Raubitschek AA. Yazaki PJ, et al. Among authors: raubitschek aa. Protein Eng Des Sel. 2004 May;17(5):481-9. doi: 10.1093/protein/gzh056. Epub 2004 Aug 17. Protein Eng Des Sel. 2004. PMID: 15316127
135 results