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Somatic evolution in the immune system: the need for germinal centers for efficient affinity maturation.
Pierre DM, Goldman D, Bar-Yam Y, Perelson AS. Pierre DM, et al. Among authors: perelson as. J Theor Biol. 1997 May 21;186(2):159-71. doi: 10.1006/jtbi.1996.0350. J Theor Biol. 1997. PMID: 9196657 Free article.
Through the use of simulation models we show that the efficiency of affinity maturation is substantially improved if mutation and selection occur in germinal centers, specialized regions of lymphoid tissues, rather than in the body as a whole. We show that confining mutati …
Through the use of simulation models we show that the efficiency of affinity maturation is substantially improved if mutation and selection …
A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies.
McCann CD, van Dorp CH, Danesh A, Ward AR, Dilling TR, Mota TM, Zale E, Stevenson EM, Patel S, Brumme CJ, Dong W, Jones DS, Andresen TL, Walker BD, Brumme ZL, Bollard CM, Perelson AS, Irvine DJ, Jones RB. McCann CD, et al. Among authors: perelson as. J Exp Med. 2021 Jul 5;218(7):e20201908. doi: 10.1084/jem.20201908. Epub 2021 May 14. J Exp Med. 2021. PMID: 33988715 Free PMC article.
505 results