Sebti SM - Search Results

1

A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice.

Kinkade R, Dasgupta P, Carie A, Pernazza D, Carless M, Pillai S, Lawrence N, Sebti SM, Chellappan S. Kinkade R, et al. Among authors: sebti sm. Cancer Res. 2008 May 15;68(10):3810-8. doi: 10.1158/0008-5472.CAN-07-6672. Cancer Res. 2008. PMID: 18483265 Free PMC article.

2

Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine.

Singh S, Davis R, Alamanda V, Pireddu R, Pernazza D, Sebti S, Lawrence N, Chellappan S. Singh S, et al. Mol Cancer Ther. 2010 Dec;9(12):3330-41. doi: 10.1158/1535-7163.MCT-10-0442. Epub 2010 Dec 7. Mol Cancer Ther. 2010. PMID: 21139044 Free PMC article.

3

TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes.

Davis R, Pillai S, Lawrence N, Sebti S, Chellappan SP. Davis R, et al. Cell Cycle. 2012 Jan 1;11(1):109-18. doi: 10.4161/cc.11.1.18473. Epub 2012 Jan 1. Cell Cycle. 2012. PMID: 22185776 Free PMC article.

4

Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.

Dasgupta P, Sun J, Wang S, Fusaro G, Betts V, Padmanabhan J, Sebti SM, Chellappan SP. Dasgupta P, et al. Among authors: sebti sm. Mol Cell Biol. 2004 Nov;24(21):9527-41. doi: 10.1128/MCB.24.21.9527-9541.2004. Mol Cell Biol. 2004. PMID: 15485920 Free PMC article.

5

Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease.

Johnson JL, Pillai S, Pernazza D, Sebti SM, Lawrence NJ, Chellappan SP. Johnson JL, et al. Among authors: sebti sm. Cancer Res. 2012 Jan 15;72(2):516-26. doi: 10.1158/0008-5472.CAN-11-2647. Epub 2011 Nov 15. Cancer Res. 2012. PMID: 22086850 Free PMC article.

6

Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.

Treviño JG, Verma M, Singh S, Pillai S, Zhang D, Pernazza D, Sebti SM, Lawrence NJ, Centeno BA, Chellappan SP. Treviño JG, et al. Among authors: sebti sm. Mol Cancer Ther. 2013 Dec;12(12):2722-34. doi: 10.1158/1535-7163.MCT-12-0719. Epub 2013 Oct 9. Mol Cancer Ther. 2013. PMID: 24107447 Free PMC article.

7

A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway.

Carie AE, Sebti SM. Carie AE, et al. Among authors: sebti sm. Oncogene. 2007 May 31;26(26):3777-88. doi: 10.1038/sj.onc.1210172. Epub 2007 Jan 29. Oncogene. 2007. PMID: 17260025

8

Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors.

Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD, Sebti SM. Sun J, et al. Among authors: sebti sm. Oncogene. 2005 Jul 7;24(29):4701-9. doi: 10.1038/sj.onc.1208391. Oncogene. 2005. PMID: 15897913

9

Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2.

Win-Piazza H, Schneeberger VE, Chen L, Pernazza D, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Win-Piazza H, et al. Among authors: sebti sm. Cancer Lett. 2012 Jul 1;320(1):81-5. doi: 10.1016/j.canlet.2012.01.034. Epub 2012 Feb 1. Cancer Lett. 2012. PMID: 22306001 Free PMC article.

10

HG-829 is a potent noncompetitive inhibitor of the ATP-binding cassette multidrug resistance transporter ABCB1.

Caceres G, Robey RW, Sokol L, McGraw KL, Clark J, Lawrence NJ, Sebti SM, Wiese M, List AF. Caceres G, et al. Among authors: sebti sm. Cancer Res. 2012 Aug 15;72(16):4204-13. doi: 10.1158/0008-5472.CAN-12-0743. Epub 2012 Jul 3. Cancer Res. 2012. PMID: 22761337 Free PMC article.

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