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Page 1
The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.
Rigazio S, Lehto HR, Tuunanen H, Någren K, Kankaanpaa M, Simi C, Borra R, Naum AG, Parkkola R, Knuuti J, Nuutila P, Iozzo P. Rigazio S, et al. Among authors: nagren k. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E413-9. doi: 10.1152/ajpendo.00744.2007. Epub 2008 May 27. Am J Physiol Endocrinol Metab. 2008. PMID: 18505832 Free article.
Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals.
Iozzo P, Bucci M, Roivainen A, Någren K, Järvisalo MJ, Kiss J, Guiducci L, Fielding B, Naum AG, Borra R, Virtanen K, Savunen T, Salvadori PA, Ferrannini E, Knuuti J, Nuutila P. Iozzo P, et al. Among authors: nagren k. Gastroenterology. 2010 Sep;139(3):846-56, 856.e1-6. doi: 10.1053/j.gastro.2010.05.039. Epub 2010 May 25. Gastroenterology. 2010. PMID: 20685204
Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities.
Bucci M, Borra R, Någren K, Maggio R, Tuunanen H, Oikonen V, Del Ry S, Viljanen T, Taittonen M, Rigazio S, Giannessi D, Parkkola R, Knuuti J, Nuutila P, Iozzo P. Bucci M, et al. Among authors: nagren k. Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E105-12. doi: 10.1152/ajpendo.00680.2010. Epub 2011 Apr 19. Am J Physiol Endocrinol Metab. 2011. PMID: 21505146 Free article. Clinical Trial.
Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans.
Bucci M, Borra R, Någren K, Pärkkä JP, Del Ry S, Maggio R, Tuunanen H, Viljanen T, Cabiati M, Rigazio S, Taittonen M, Pagotto U, Parkkola R, Opie LH, Nuutila P, Knuuti J, Iozzo P. Bucci M, et al. Among authors: nagren k. Cardiovasc Ther. 2012 Dec;30(6):333-41. doi: 10.1111/j.1755-5922.2011.00275.x. Epub 2011 Jul 31. Cardiovasc Ther. 2012. PMID: 21884010 Free article.
[11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia.
Guiducci L, Järvisalo M, Kiss J, Någren K, Viljanen A, Naum AG, Gastaldelli A, Savunen T, Knuuti J, Salvadori PA, Ferrannini E, Nuutila P, Iozzo P. Guiducci L, et al. Among authors: nagren k. Nucl Med Biol. 2006 May;33(4):521-8. doi: 10.1016/j.nucmedbio.2006.02.003. Epub 2006 May 2. Nucl Med Biol. 2006. PMID: 16720244
Pancreatic glucose uptake in vivo in men with newly diagnosed type 1 diabetes.
Kalliokoski T, Nuutila P, Virtanen KA, Iozzo P, Bucci M, Svedström E, Roivainen A, Någren K, Viljanen T, Minn H, Knuuti J, Rönnemaa T, Simell O. Kalliokoski T, et al. Among authors: nagren k. J Clin Endocrinol Metab. 2008 May;93(5):1909-14. doi: 10.1210/jc.2006-2533. Epub 2008 Feb 19. J Clin Endocrinol Metab. 2008. PMID: 18285422
218 results