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206 results

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Page 1
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.
Cappellacci L, Franchetti P, Vita P, Petrelli R, Lavecchia A, Jayaram HN, Saiko P, Graser G, Szekeres T, Grifantini M. Cappellacci L, et al. Among authors: lavecchia a. J Med Chem. 2008 Jul 24;51(14):4260-9. doi: 10.1021/jm800205c. Epub 2008 Jun 28. J Med Chem. 2008. PMID: 18588281
Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.
Vianello P, Albinati A, Pinna GA, Lavecchia A, Marinelli L, Borea PA, Gessi S, Fadda P, Tronci S, Cignarella G. Vianello P, et al. Among authors: lavecchia a. J Med Chem. 2000 Jun 1;43(11):2115-23. doi: 10.1021/jm991140q. J Med Chem. 2000. PMID: 10841790
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.
Primofiore G, Settimo FD, Taliani S, Marini AM, Novellino E, Greco G, Lavecchia A, Besnard F, Trincavelli L, Costa B, Martini C. Primofiore G, et al. Among authors: lavecchia a. J Med Chem. 2001 Jul 5;44(14):2286-97. doi: 10.1021/jm010827j. J Med Chem. 2001. PMID: 11428922
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Mai A, Sbardella G, Artico M, Ragno R, Massa S, Novellino E, Greco G, Lavecchia A, Musiu C, La Colla M, Murgioni C, La Colla P, Loddo R. Mai A, et al. Among authors: lavecchia a. J Med Chem. 2001 Aug 2;44(16):2544-54. doi: 10.1021/jm010853h. J Med Chem. 2001. PMID: 11472208
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.
Novellino E, Abignente E, Cosimelli B, Greco G, Iadanza M, Laneri S, Lavecchia A, Rimoli MG, Settimo FD, Primofiore G, Tuscano D, Trincavelli L, Martini C. Novellino E, et al. Among authors: lavecchia a. J Med Chem. 2002 Nov 7;45(23):5030-6. doi: 10.1021/jm020911e. J Med Chem. 2002. PMID: 12408713
Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity.
Bolognese A, Correale G, Manfra M, Lavecchia A, Mazzoni O, Novellino E, Barone V, Pani A, Tramontano E, La Colla P, Murgioni C, Serra I, Setzu G, Loddo R. Bolognese A, et al. Among authors: lavecchia a. J Med Chem. 2002 Nov 21;45(24):5205-16. doi: 10.1021/jm020913z. J Med Chem. 2002. PMID: 12431048
206 results