Deshayes K - Search Results

1

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D. Varfolomeev E, et al. Among authors: deshayes k. J Biol Chem. 2008 Sep 5;283(36):24295-9. doi: 10.1074/jbc.C800128200. Epub 2008 Jul 11. J Biol Chem. 2008. PMID: 18621737 Free PMC article.

2

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).

Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM. Vucic D, et al. Among authors: deshayes k. J Biol Chem. 2002 Apr 5;277(14):12275-9. doi: 10.1074/jbc.M112045200. Epub 2002 Jan 18. J Biol Chem. 2002. PMID: 11801603 Free article.

3

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D. Varfolomeev E, et al. Among authors: deshayes k. Cell. 2007 Nov 16;131(4):669-81. doi: 10.1016/j.cell.2007.10.030. Cell. 2007. PMID: 18022362 Free article.

4

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D. Blankenship JW, et al. Among authors: deshayes k. Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885. Biochem J. 2009. PMID: 18939944

5

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, Maurer B, Fedorova AV, Dynek JN, Koehler M, Hymowitz SG, Tsui V, Deshayes K, Fairbrother WJ, Flygare JA, Vucic D. Ndubaku C, et al. Among authors: deshayes k. ACS Chem Biol. 2009 Jul 17;4(7):557-66. doi: 10.1021/cb900083m. ACS Chem Biol. 2009. PMID: 19492850

6

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D. Dynek JN, et al. Among authors: deshayes k. EMBO J. 2010 Dec 15;29(24):4198-209. doi: 10.1038/emboj.2010.300. Epub 2010 Nov 26. EMBO J. 2010. PMID: 21113135 Free PMC article.

7

Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Varfolomeev E, Goncharov T, Maecker H, Zobel K, Kömüves LG, Deshayes K, Vucic D. Varfolomeev E, et al. Among authors: deshayes k. Sci Signal. 2012 Mar 20;5(216):ra22. doi: 10.1126/scisignal.2001878. Sci Signal. 2012. PMID: 22434933

8

OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

Goncharov T, Niessen K, de Almagro MC, Izrael-Tomasevic A, Fedorova AV, Varfolomeev E, Arnott D, Deshayes K, Kirkpatrick DS, Vucic D. Goncharov T, et al. Among authors: deshayes k. EMBO J. 2013 Apr 17;32(8):1103-14. doi: 10.1038/emboj.2013.62. Epub 2013 Mar 22. EMBO J. 2013. PMID: 23524849 Free PMC article.

9

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Vucic D, et al. Among authors: deshayes k. Biochem J. 2005 Jan 1;385(Pt 1):11-20. doi: 10.1042/BJ20041108. Biochem J. 2005. PMID: 15485396 Free PMC article.

10

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Zobel K, et al. Among authors: deshayes k. ACS Chem Biol. 2006 Sep 19;1(8):525-33. doi: 10.1021/cb600276q. ACS Chem Biol. 2006. PMID: 17168540

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