Klar U - Search Results

1

Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks.

Höhne A, Mu L, Honer M, Schubiger PA, Ametamey SM, Graham K, Stellfeld T, Borkowski S, Berndorff D, Klar U, Voigtmann U, Cyr JE, Friebe M, Dinkelborg L, Srinivasan A. Höhne A, et al. Among authors: klar u. Bioconjug Chem. 2008 Sep;19(9):1871-9. doi: 10.1021/bc800157h. Epub 2008 Aug 28. Bioconjug Chem. 2008. PMID: 18754574

2

Silicon-based building blocks for one-step 18F-radiolabeling of peptides for PET imaging.

Mu L, Höhne A, Schubiger PA, Ametamey SM, Graham K, Cyr JE, Dinkelborg L, Stellfeld T, Srinivasan A, Voigtmann U, Klar U. Mu L, et al. Among authors: klar u. Angew Chem Int Ed Engl. 2008;47(26):4922-5. doi: 10.1002/anie.200705854. Angew Chem Int Ed Engl. 2008. PMID: 18496798 No abstract available.

3

Organofluorosilanes as model compounds for 18F-labeled silicon-based PET tracers and their hydrolytic stability: experimental data and theoretical calculations (PET = positron emission tomography).

Höhne A, Yu L, Mu L, Reiher M, Voigtmann U, Klar U, Graham K, Schubiger PA, Ametamey SM. Höhne A, et al. Among authors: klar u. Chemistry. 2009;15(15):3736-43. doi: 10.1002/chem.200802437. Chemistry. 2009. PMID: 19267382

4

Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.

Klar U, Buchmann B, Schwede W, Skuballa W, Hoffmann J, Lichtner RB. Klar U, et al. Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7942-8. doi: 10.1002/anie.200602785. Angew Chem Int Ed Engl. 2006. PMID: 17006870 No abstract available.

5

Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate.

Klar U, Hoffmann J, Giurescu M. Klar U, et al. Expert Opin Investig Drugs. 2008 Nov;17(11):1735-48. doi: 10.1517/13543784.17.11.1735. Expert Opin Investig Drugs. 2008. PMID: 18922109 Review.

6

Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone.

Hoffmann J, Vitale I, Buchmann B, Galluzzi L, Schwede W, Senovilla L, Skuballa W, Vivet S, Lichtner RB, Vicencio JM, Panaretakis T, Siemeister G, Lage H, Nanty L, Hammer S, Mittelstaedt K, Winsel S, Eschenbrenner J, Castedo M, Demarche C, Klar U, Kroemer G. Hoffmann J, et al. Among authors: klar u. Cancer Res. 2008 Jul 1;68(13):5301-8. doi: 10.1158/0008-5472.CAN-08-0237. Cancer Res. 2008. PMID: 18593931

7

Subcellular distribution of epothilones in human tumor cells.

Lichtner RB, Rotgeri A, Bunte T, Buchmann B, Hoffmann J, Schwede W, Skuballa W, Klar U. Lichtner RB, et al. Among authors: klar u. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11743-8. doi: 10.1073/pnas.171023398. Epub 2001 Sep 18. Proc Natl Acad Sci U S A. 2001. PMID: 11562452 Free PMC article.

8

Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.

Lichtner RB, Menrad A, Sommer A, Klar U, Schneider MR. Lichtner RB, et al. Among authors: klar u. Cancer Res. 2001 Aug 1;61(15):5790-5. Cancer Res. 2001. PMID: 11479217

9

Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases.

Hoffmann J, Fichtner I, Lemm M, Lienau P, Hess-Stumpp H, Rotgeri A, Hofmann B, Klar U. Hoffmann J, et al. Among authors: klar u. Neuro Oncol. 2009 Apr;11(2):158-66. doi: 10.1215/15228517-2008-072. Epub 2008 Sep 9. Neuro Oncol. 2009. PMID: 18780814 Free PMC article.

10

Sagopilone inhibits breast cancer bone metastasis and bone destruction due to simultaneous inhibition of both tumor growth and bone resorption.

Strube A, Hoffmann J, Stepina E, Hauff P, Klar U, Käkönen SM. Strube A, et al. Among authors: klar u. Clin Cancer Res. 2009 Jun 1;15(11):3751-9. doi: 10.1158/1078-0432.CCR-08-3123. Epub 2009 May 26. Clin Cancer Res. 2009. PMID: 19470728

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