Cox R - Search Results

1

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM. Girard CA, et al. Among authors: cox r. J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8. J Clin Invest. 2009. PMID: 19065048 Free PMC article.

2

A gene-driven approach to the identification of ENU mutants in the mouse.

Coghill EL, Hugill A, Parkinson N, Davison C, Glenister P, Clements S, Hunter J, Cox RD, Brown SD. Coghill EL, et al. Nat Genet. 2002 Mar;30(3):255-6. doi: 10.1038/ng847. Epub 2002 Feb 19. Nat Genet. 2002. PMID: 11850622

3

A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.

Toye AA, Moir L, Hugill A, Bentley L, Quarterman J, Mijat V, Hough T, Goldsworthy M, Haynes A, Hunter AJ, Browne M, Spurr N, Cox RD. Toye AA, et al. Diabetes. 2004 Jun;53(6):1577-83. doi: 10.2337/diabetes.53.6.1577. Diabetes. 2004. PMID: 15161764

4

ENU mutagenesis in the mouse: application to human genetic disease.

Nolan PM, Hugill A, Cox RD. Nolan PM, et al. Brief Funct Genomic Proteomic. 2002 Oct;1(3):278-89. doi: 10.1093/bfgp/1.3.278. Brief Funct Genomic Proteomic. 2002. PMID: 15239894 Review.

5

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.

Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD. Toye AA, et al. Among authors: cox rd. Diabetologia. 2005 Apr;48(4):675-86. doi: 10.1007/s00125-005-1680-z. Epub 2005 Feb 24. Diabetologia. 2005. PMID: 15729571 Free article.

6

Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.

Freeman H, Shimomura K, Horner E, Cox RD, Ashcroft FM. Freeman H, et al. Cell Metab. 2006 Jan;3(1):35-45. doi: 10.1016/j.cmet.2005.10.008. Cell Metab. 2006. PMID: 16399503 Free article.

7

Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice.

Freeman HC, Hugill A, Dear NT, Ashcroft FM, Cox RD. Freeman HC, et al. Diabetes. 2006 Jul;55(7):2153-6. doi: 10.2337/db06-0358. Diabetes. 2006. PMID: 16804088

8

Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress.

Freeman H, Shimomura K, Cox RD, Ashcroft FM. Freeman H, et al. Among authors: cox rd. Biochem Soc Trans. 2006 Nov;34(Pt 5):806-10. doi: 10.1042/BST0340806. Biochem Soc Trans. 2006. PMID: 17052203

9

R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

Zhang Q, Bengtsson M, Partridge C, Salehi A, Braun M, Cox R, Eliasson L, Johnson PR, Renström E, Schneider T, Berggren PO, Göpel S, Ashcroft FM, Rorsman P. Zhang Q, et al. Among authors: cox r. Nat Cell Biol. 2007 Apr;9(4):453-60. doi: 10.1038/ncb1563. Epub 2007 Mar 18. Nat Cell Biol. 2007. PMID: 17369816

10

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

MacDonald PE, De Marinis YZ, Ramracheya R, Salehi A, Ma X, Johnson PR, Cox R, Eliasson L, Rorsman P. MacDonald PE, et al. Among authors: cox r. PLoS Biol. 2007 Jun;5(6):e143. doi: 10.1371/journal.pbio.0050143. PLoS Biol. 2007. PMID: 17503968 Free PMC article.

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