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BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma.
Gaitonde S, De SK, Tcherpakov M, Dewing A, Yuan H, Riel-Mehan M, Krajewski S, Robertson G, Pellecchia M, Ronai Z. Gaitonde S, et al. Among authors: de sk. Pigment Cell Melanoma Res. 2009 Apr;22(2):187-95. doi: 10.1111/j.1755-148X.2009.00544.x. Epub 2009 Jan 17. Pigment Cell Melanoma Res. 2009. PMID: 19175524 Free PMC article.
Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.
Feng Y, Lau E, Scortegagna M, Ruller C, De SK, Barile E, Krajewski S, Aza-Blanc P, Williams R, Pinkerton AB, Jackson M, Chin L, Pellecchia M, Bosenberg M, Ronai ZA. Feng Y, et al. Among authors: de sk. Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42. doi: 10.1111/pcmr.12033. Epub 2012 Nov 2. Pigment Cell Melanoma Res. 2013. PMID: 23035722 Free PMC article.
Structure-based design of covalent Siah inhibitors.
Stebbins JL, Santelli E, Feng Y, De SK, Purves A, Motamedchaboki K, Wu B, Ronai ZA, Liddington RC, Pellecchia M. Stebbins JL, et al. Among authors: de sk. Chem Biol. 2013 Aug 22;20(8):973-82. doi: 10.1016/j.chembiol.2013.06.008. Epub 2013 Jul 25. Chem Biol. 2013. PMID: 23891150 Free PMC article.
PDK1 inhibitors.
Barile E, De SK, Pellecchia M. Barile E, et al. Among authors: de sk. Pharm Pat Anal. 2012 May;1(2):145-63. doi: 10.4155/ppa.12.17. Pharm Pat Anal. 2012. PMID: 24236780 Free PMC article. Review.
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. Stebbins JL, et al. Among authors: de sk. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13. doi: 10.1073/pnas.0805677105. Epub 2008 Oct 15. Proc Natl Acad Sci U S A. 2008. PMID: 18922779 Free PMC article.
198 results