Manoharan M - Search Results

1

Development of lipidoid-siRNA formulations for systemic delivery to the liver.

Akinc A, Goldberg M, Qin J, Dorkin JR, Gamba-Vitalo C, Maier M, Jayaprakash KN, Jayaraman M, Rajeev KG, Manoharan M, Koteliansky V, Röhl I, Leshchiner ES, Langer R, Anderson DG. Akinc A, et al. Among authors: manoharan m. Mol Ther. 2009 May;17(5):872-9. doi: 10.1038/mt.2009.36. Epub 2009 Mar 3. Mol Ther. 2009. PMID: 19259063 Free PMC article.

2

Synthesis of chimeric oligonucleotides containing phosphodiester, phosphorothioate, and phosphoramidate linkages.

Maier MA, Guzaev AP, Manoharan M. Maier MA, et al. Among authors: manoharan m. Org Lett. 2000 Jun 29;2(13):1819-22. doi: 10.1021/ol005842h. Org Lett. 2000. PMID: 10891166

3

Synthesis of novel 3'-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides.

An H, Wang T, Maier MA, Manoharan M, Ross BS, Cook PD. An H, et al. Among authors: manoharan m. J Org Chem. 2001 Apr 20;66(8):2789-801. doi: 10.1021/jo001699u. J Org Chem. 2001. PMID: 11304203

4

Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain.

Karras JG, Maier MA, Lu T, Watt A, Manoharan M. Karras JG, et al. Among authors: manoharan m. Biochemistry. 2001 Jul 3;40(26):7853-9. doi: 10.1021/bi010263l. Biochemistry. 2001. PMID: 11425312

5

High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues.

Rajeev KG, Maier MA, Lesnik EA, Manoharan M. Rajeev KG, et al. Among authors: manoharan m. Org Lett. 2002 Dec 12;4(25):4395-8. doi: 10.1021/ol027026a. Org Lett. 2002. PMID: 12465896

6

Synthesis of antisense oligonucleotides conjugated to a multivalent carbohydrate cluster for cellular targeting.

Maier MA, Yannopoulos CG, Mohamed N, Roland A, Fritz H, Mohan V, Just G, Manoharan M. Maier MA, et al. Among authors: manoharan m. Bioconjug Chem. 2003 Jan-Feb;14(1):18-29. doi: 10.1021/bc020028v. Bioconjug Chem. 2003. PMID: 12526688

7

2'-modified-2-thiothymidine oligonucleotides.

Rajeev KG, Prakash TP, Manoharan M. Rajeev KG, et al. Among authors: manoharan m. Org Lett. 2003 Aug 21;5(17):3005-8. doi: 10.1021/ol0348607. Org Lett. 2003. PMID: 12916967

8

RNA interference and chemically modified siRNAs.

Manoharan M. Manoharan M. Nucleic Acids Res Suppl. 2003;(3):115-6. doi: 10.1093/nass/3.1.115. Nucleic Acids Res Suppl. 2003. PMID: 14510407

9

Synthesis and characterization of oligonucleotides containing conformationally constrained bicyclo[3.1.0]hexane pseudosugar analogs.

Maier MA, Choi Y, Gaus H, Barchi JJ Jr, Marquez VE, Manoharan M. Maier MA, et al. Among authors: manoharan m. Nucleic Acids Res. 2004 Jul 9;32(12):3642-50. doi: 10.1093/nar/gkh667. Print 2004. Nucleic Acids Res. 2004. PMID: 15247346 Free PMC article.

10

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, John M, Kesavan V, Lavine G, Pandey RK, Racie T, Rajeev KG, Röhl I, Toudjarska I, Wang G, Wuschko S, Bumcrot D, Koteliansky V, Limmer S, Manoharan M, Vornlocher HP. Soutschek J, et al. Among authors: manoharan m. Nature. 2004 Nov 11;432(7014):173-8. doi: 10.1038/nature03121. Nature. 2004. PMID: 15538359 Free article.

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