He K - Search Results

1

Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.

Zhang D, He K, Raghavan N, Wang L, Mitroka J, Maxwell BD, Knabb RM, Frost C, Schuster A, Hao F, Gu Z, Humphreys WG, Grossman SJ. Zhang D, et al. Among authors: he k. Drug Metab Dispos. 2009 Aug;37(8):1738-48. doi: 10.1124/dmd.108.025981. Epub 2009 May 6. Drug Metab Dispos. 2009. PMID: 19420130 Clinical Trial.

2

Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs.

Zhang D, Raghavan N, Chen SY, Zhang H, Quan M, Lecureux L, Patrone LM, Lam PY, Bonacorsi SJ, Knabb RM, Skiles GL, He K. Zhang D, et al. Among authors: he k. Drug Metab Dispos. 2008 Feb;36(2):303-15. doi: 10.1124/dmd.107.018416. Epub 2007 Nov 5. Drug Metab Dispos. 2008. PMID: 17984286

3

Metabolism and disposition of dasatinib after oral administration to humans.

Christopher LJ, Cui D, Wu C, Luo R, Manning JA, Bonacorsi SJ, Lago M, Allentoff A, Lee FY, McCann B, Galbraith S, Reitberg DP, He K, Barros A Jr, Blackwood-Chirchir A, Humphreys WG, Iyer RA. Christopher LJ, et al. Among authors: he k. Drug Metab Dispos. 2008 Jul;36(7):1357-64. doi: 10.1124/dmd.107.018267. Epub 2008 Apr 17. Drug Metab Dispos. 2008. PMID: 18420784

4

Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys.

Christopher LJ, Cui D, Li W, Barros A Jr, Arora VK, Zhang H, Wang L, Zhang D, Manning JA, He K, Fletcher AM, Ogan M, Lago M, Bonacorsi SJ, Humphreys WG, Iyer RA. Christopher LJ, et al. Among authors: he k. Drug Metab Dispos. 2008 Jul;36(7):1341-56. doi: 10.1124/dmd.107.018234. Epub 2008 Apr 17. Drug Metab Dispos. 2008. PMID: 18420785

5

Apixaban metabolism and pharmacokinetics after oral administration to humans.

Raghavan N, Frost CE, Yu Z, He K, Zhang H, Humphreys WG, Pinto D, Chen S, Bonacorsi S, Wong PC, Zhang D. Raghavan N, et al. Among authors: he k. Drug Metab Dispos. 2009 Jan;37(1):74-81. doi: 10.1124/dmd.108.023143. Epub 2008 Oct 2. Drug Metab Dispos. 2009. PMID: 18832478

6

Sulfation of o-demethyl apixaban: enzyme identification and species comparison.

Wang L, Raghavan N, He K, Luettgen JM, Humphreys WG, Knabb RM, Pinto DJ, Zhang D. Wang L, et al. Among authors: he k. Drug Metab Dispos. 2009 Apr;37(4):802-8. doi: 10.1124/dmd.108.025593. Epub 2009 Jan 8. Drug Metab Dispos. 2009. PMID: 19131519

7

Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits.

Zhang D, He K, Raghavan N, Wang L, Crain EJ, He B, Xin B, Luettgen JM, Wong PC. Zhang D, et al. Among authors: he k, he b. J Thromb Thrombolysis. 2010 Jan;29(1):70-80. doi: 10.1007/s11239-009-0401-8. J Thromb Thrombolysis. 2010. PMID: 19851712

8

In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.

Wang L, Zhang D, Raghavan N, Yao M, Ma L, Frost CE, Maxwell BD, Chen SY, He K, Goosen TC, Humphreys WG, Grossman SJ. Wang L, et al. Among authors: he k. Drug Metab Dispos. 2010 Mar;38(3):448-58. doi: 10.1124/dmd.109.029694. Epub 2009 Nov 25. Drug Metab Dispos. 2010. PMID: 19940026

9

Tissue distribution and elimination of [14C]apixaban in rats.

Wang L, He K, Maxwell B, Grossman SJ, Tremaine LM, Humphreys WG, Zhang D. Wang L, et al. Among authors: he k. Drug Metab Dispos. 2011 Feb;39(2):256-64. doi: 10.1124/dmd.110.036442. Epub 2010 Nov 11. Drug Metab Dispos. 2011. PMID: 21071521

10

Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor.

He K, Luettgen JM, Zhang D, He B, Grace JE Jr, Xin B, Pinto DJ, Wong PC, Knabb RM, Lam PY, Wexler RR, Grossman SJ. He K, et al. Among authors: he b. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):129-39. doi: 10.1007/s13318-011-0037-x. Epub 2011 Apr 2. Eur J Drug Metab Pharmacokinet. 2011. PMID: 21461793

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