Agarwal S - Search Results

1

P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib.

Chen Y, Agarwal S, Shaik NM, Chen C, Yang Z, Elmquist WF. Chen Y, et al. Among authors: agarwal s. J Pharmacol Exp Ther. 2009 Sep;330(3):956-63. doi: 10.1124/jpet.109.154781. Epub 2009 Jun 2. J Pharmacol Exp Ther. 2009. PMID: 19491323

2

Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)-mediated interactions: consideration of multiple binding sites in in vitro assay design.

Giri N, Agarwal S, Shaik N, Pan G, Chen Y, Elmquist WF. Giri N, et al. Among authors: agarwal s. Drug Metab Dispos. 2009 Mar;37(3):560-70. doi: 10.1124/dmd.108.022046. Epub 2008 Dec 4. Drug Metab Dispos. 2009. PMID: 19056916 Free PMC article.

3

Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux.

Agarwal S, Sane R, Gallardo JL, Ohlfest JR, Elmquist WF. Agarwal S, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):147-55. doi: 10.1124/jpet.110.167601. Epub 2010 Apr 26. J Pharmacol Exp Ther. 2010. PMID: 20421331 Free PMC article.

4

The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain.

Agarwal S, Sane R, Ohlfest JR, Elmquist WF. Agarwal S, et al. J Pharmacol Exp Ther. 2011 Jan;336(1):223-33. doi: 10.1124/jpet.110.175034. Epub 2010 Oct 15. J Pharmacol Exp Ther. 2011. PMID: 20952483 Free PMC article.

5

Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up.

Agarwal S, Hartz AM, Elmquist WF, Bauer B. Agarwal S, et al. Curr Pharm Des. 2011;17(26):2793-802. doi: 10.2174/138161211797440186. Curr Pharm Des. 2011. PMID: 21827403 Free PMC article. Review.

6

Brain distribution of cediranib is limited by active efflux at the blood-brain barrier.

Wang T, Agarwal S, Elmquist WF. Wang T, et al. Among authors: agarwal s. J Pharmacol Exp Ther. 2012 May;341(2):386-95. doi: 10.1124/jpet.111.190488. Epub 2012 Feb 8. J Pharmacol Exp Ther. 2012. PMID: 22323823 Free PMC article.

7

Insight into the cooperation of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) at the blood-brain barrier: a case study examining sorafenib efflux clearance.

Agarwal S, Elmquist WF. Agarwal S, et al. Mol Pharm. 2012 Mar 5;9(3):678-84. doi: 10.1021/mp200465c. Epub 2012 Feb 22. Mol Pharm. 2012. PMID: 22335402 Free PMC article.

8

Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and P-gp/Bcrp knockout mice.

Agarwal S, Uchida Y, Mittapalli RK, Sane R, Terasaki T, Elmquist WF. Agarwal S, et al. Drug Metab Dispos. 2012 Jun;40(6):1164-9. doi: 10.1124/dmd.112.044719. Epub 2012 Mar 8. Drug Metab Dispos. 2012. PMID: 22401960 Free PMC article.

9

Brain distribution and bioavailability of elacridar after different routes of administration in the mouse.

Sane R, Agarwal S, Elmquist WF. Sane R, et al. Among authors: agarwal s. Drug Metab Dispos. 2012 Aug;40(8):1612-9. doi: 10.1124/dmd.112.045930. Epub 2012 May 18. Drug Metab Dispos. 2012. PMID: 22611067 Free PMC article.

10

Active efflux of Dasatinib from the brain limits efficacy against murine glioblastoma: broad implications for the clinical use of molecularly targeted agents.

Agarwal S, Mittapalli RK, Zellmer DM, Gallardo JL, Donelson R, Seiler C, Decker SA, Santacruz KS, Pokorny JL, Sarkaria JN, Elmquist WF, Ohlfest JR. Agarwal S, et al. Mol Cancer Ther. 2012 Oct;11(10):2183-92. doi: 10.1158/1535-7163.MCT-12-0552. Epub 2012 Aug 13. Mol Cancer Ther. 2012. PMID: 22891038 Free PMC article.

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