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15 results

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Page 1
Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Thompson SK, Washburn DG, Frazee JS, Madauss KP, Hoang TH, Lapinski L, Grygielko ET, Glace LE, Trizna W, Williams SP, Duraiswami C, Bray JD, Laping NJ. Thompson SK, et al. Among authors: duraiswami c. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4777-80. doi: 10.1016/j.bmcl.2009.06.055. Epub 2009 Jun 17. Bioorg Med Chem Lett. 2009. PMID: 19595590
Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.
Washburn DG, Hoang TH, Campobasso N, Smallwood A, Parks DJ, Webb CL, Frank KA, Nord M, Duraiswami C, Evans C, Jaye M, Thompson SK. Washburn DG, et al. Among authors: duraiswami c. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1097-100. doi: 10.1016/j.bmcl.2009.01.004. Epub 2009 Jan 9. Bioorg Med Chem Lett. 2009. PMID: 19167885
Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists.
Washburn DG, Hoang TH, Frazee JS, Johnson L, Hammond M, Manns S, Madauss KP, Williams SP, Duraiswami C, Tran TB, Stewart EL, Grygielko ET, Glace LE, Trizna W, Nagilla R, Bray JD, Thompson SK. Washburn DG, et al. Among authors: duraiswami c. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4664-8. doi: 10.1016/j.bmcl.2009.06.081. Epub 2009 Jun 25. Bioorg Med Chem Lett. 2009. PMID: 19616429
2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists.
Wang Y, Duraiswami C, Madauss KP, Tran TB, Williams SP, Deng SJ, Graybill TL, Hammond M, Jones DG, Grygielko ET, Bray JD, Thompson SK. Wang Y, et al. Among authors: duraiswami c. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4916-9. doi: 10.1016/j.bmcl.2009.07.100. Epub 2009 Jul 23. Bioorg Med Chem Lett. 2009. PMID: 19664922
Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
Kallander LS, Washburn DG, Hoang TH, Frazee JS, Stoy P, Johnson L, Lu Q, Hammond M, Barton LS, Patterson JR, Azzarano LM, Nagilla R, Madauss KP, Williams SP, Stewart EL, Duraiswami C, Grygielko ET, Xu X, Laping NJ, Bray JD, Thompson SK. Kallander LS, et al. Among authors: duraiswami c. Bioorg Med Chem Lett. 2010 Jan 1;20(1):371-4. doi: 10.1016/j.bmcl.2009.10.092. Epub 2009 Oct 25. Bioorg Med Chem Lett. 2010. PMID: 19926282
High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome.
Harris PA, Duraiswami C, Fisher DT, Fornwald J, Hoffman SJ, Hofmann G, Jiang M, Lehr R, McCormick PM, Nickels L, Schwartz B, Wu Z, Zhang G, Marquis RW, Bertin J, Gough PJ. Harris PA, et al. Among authors: duraiswami c. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2739-43. doi: 10.1016/j.bmcl.2015.05.032. Epub 2015 May 19. Bioorg Med Chem Lett. 2015. PMID: 26022841
Solution of the conformation and alignment tensors for the binding of trimethoprim and its analogs to dihydrofolate reductase: 3D-quantitative structure-activity relationship study using molecular shape analysis, 3-way partial least-squares regression, and 3-way factor analysis.
Dunn WJ 3rd, Hopfinger AJ, Catana C, Duraiswami C. Dunn WJ 3rd, et al. Among authors: duraiswami c. J Med Chem. 1996 Nov 22;39(24):4825-32. doi: 10.1021/jm960491r. J Med Chem. 1996. PMID: 8941396
15 results