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Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.
Ardi VC, Van den Steen PE, Opdenakker G, Schweighofer B, Deryugina EI, Quigley JP. Ardi VC, et al. Among authors: opdenakker g. J Biol Chem. 2009 Sep 18;284(38):25854-66. doi: 10.1074/jbc.M109.033472. Epub 2009 Jul 16. J Biol Chem. 2009. PMID: 19608737 Free PMC article.
Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1.
Vandooren J, Born B, Solomonov I, Zajac E, Saldova R, Senske M, Ugarte-Berzal E, Martens E, Van den Steen PE, Van Damme J, Garcia-Pardo A, Froeyen M, Deryugina EI, Quigley JP, Moestrup SK, Rudd PM, Sagi I, Opdenakker G. Vandooren J, et al. Among authors: opdenakker g. Biochem J. 2015 Jan 15;465(2):259-70. doi: 10.1042/BJ20140418. Biochem J. 2015. PMID: 25360794 Free PMC article.
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.
Van den Steen PE, Van Aelst I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, Moestrup SK, Fry S, Royle L, Wormald MR, Wallis R, Rudd PM, Dwek RA, Opdenakker G. Van den Steen PE, et al. Among authors: opdenakker g. J Biol Chem. 2006 Jul 7;281(27):18626-37. doi: 10.1074/jbc.M512308200. Epub 2006 May 3. J Biol Chem. 2006. PMID: 16672230 Free article.
492 results