Stebbins JL - Search Results

1

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis.

Shah M, Stebbins JL, Dewing A, Qi J, Pellecchia M, Ronai ZA. Shah M, et al. Among authors: stebbins jl. Pigment Cell Melanoma Res. 2009 Dec;22(6):799-808. doi: 10.1111/j.1755-148X.2009.00628.x. Epub 2009 Aug 27. Pigment Cell Melanoma Res. 2009. PMID: 19712206 Free PMC article.

2

Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways.

Feng Y, Barile E, De SK, Stebbins JL, Cortez A, Aza-Blanc P, Villanueva J, Heryln M, Krajewski S, Pellecchia M, Ronai ZA, Chiang GG. Feng Y, et al. Among authors: stebbins jl. Pigment Cell Melanoma Res. 2011 Aug;24(4):703-13. doi: 10.1111/j.1755-148X.2011.00867.x. Epub 2011 Jun 6. Pigment Cell Melanoma Res. 2011. PMID: 21592316 Free PMC article.

3

A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors.

Chen J, Zhang Z, Stebbins JL, Zhang X, Hoffman R, Moore A, Pellecchia M. Chen J, et al. Among authors: stebbins jl. ACS Chem Biol. 2007 May 22;2(5):329-36. doi: 10.1021/cb700025j. Epub 2007 Apr 27. ACS Chem Biol. 2007. PMID: 17465519

4

Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.

De SK, Chen V, Stebbins JL, Chen LH, Cellitti JF, Machleidt T, Barile E, Riel-Mehan M, Dahl R, Yang L, Emdadi A, Murphy R, Pellecchia M. De SK, et al. Among authors: stebbins jl. Bioorg Med Chem. 2010 Jan 15;18(2):590-6. doi: 10.1016/j.bmc.2009.12.013. Epub 2009 Dec 11. Bioorg Med Chem. 2010. PMID: 20045647 Free PMC article.

5

Structure-based design of covalent Siah inhibitors.

Stebbins JL, Santelli E, Feng Y, De SK, Purves A, Motamedchaboki K, Wu B, Ronai ZA, Liddington RC, Pellecchia M. Stebbins JL, et al. Chem Biol. 2013 Aug 22;20(8):973-82. doi: 10.1016/j.chembiol.2013.06.008. Epub 2013 Jul 25. Chem Biol. 2013. PMID: 23891150 Free PMC article.

6

A structure-based approach to retinoid X receptor-alpha inhibition.

Stebbins JL, Jung D, Leone M, Zhang XK, Pellecchia M. Stebbins JL, et al. J Biol Chem. 2006 Jun 16;281(24):16643-8. doi: 10.1074/jbc.M600318200. Epub 2006 Apr 10. J Biol Chem. 2006. PMID: 16606625 Free article.

7

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.

Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. Stebbins JL, et al. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13. doi: 10.1073/pnas.0805677105. Epub 2008 Oct 15. Proc Natl Acad Sci U S A. 2008. PMID: 18922779 Free PMC article.

8

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors.

De SK, Chen LH, Stebbins JL, Machleidt T, Riel-Mehan M, Dahl R, Chen V, Yuan H, Barile E, Emdadi A, Murphy R, Pellecchia M. De SK, et al. Among authors: stebbins jl. Bioorg Med Chem. 2009 Apr 1;17(7):2712-7. doi: 10.1016/j.bmc.2009.02.046. Epub 2009 Feb 26. Bioorg Med Chem. 2009. PMID: 19282190 Free PMC article.

9

Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase.

De SK, Barile E, Chen V, Stebbins JL, Cellitti JF, Machleidt T, Carlson CB, Yang L, Dahl R, Pellecchia M. De SK, et al. Among authors: stebbins jl. Bioorg Med Chem. 2011 Apr 15;19(8):2582-8. doi: 10.1016/j.bmc.2011.03.017. Epub 2011 Mar 12. Bioorg Med Chem. 2011. PMID: 21458276 Free PMC article.

10

Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor.

Stebbins JL, De SK, Pavlickova P, Chen V, Machleidt T, Chen LH, Kuntzen C, Kitada S, Karin M, Pellecchia M. Stebbins JL, et al. J Med Chem. 2011 Sep 22;54(18):6206-14. doi: 10.1021/jm200479c. Epub 2011 Aug 23. J Med Chem. 2011. PMID: 21815634 Free PMC article.

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