Harden TK - Search Results

1

Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.

Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK. Carter RL, et al. Among authors: harden tk. Mol Pharmacol. 2009 Dec;76(6):1341-8. doi: 10.1124/mol.109.058578. Epub 2009 Sep 16. Mol Pharmacol. 2009. PMID: 19759354 Free PMC article.

2

Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist.

Waldo GL, Corbitt J, Boyer JL, Ravi G, Kim HS, Ji XD, Lacy J, Jacobson KA, Harden TK. Waldo GL, et al. Among authors: harden tk. Mol Pharmacol. 2002 Nov;62(5):1249-57. doi: 10.1124/mol.62.5.1249. Mol Pharmacol. 2002. PMID: 12391289 Free PMC article.

3

Release of cellular UDP-glucose as a potential extracellular signaling molecule.

Lazarowski ER, Shea DA, Boucher RC, Harden TK. Lazarowski ER, et al. Among authors: harden tk. Mol Pharmacol. 2003 May;63(5):1190-7. doi: 10.1124/mol.63.5.1190. Mol Pharmacol. 2003. PMID: 12695547

4

Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules.

Lazarowski ER, Boucher RC, Harden TK. Lazarowski ER, et al. Among authors: harden tk. Mol Pharmacol. 2003 Oct;64(4):785-95. doi: 10.1124/mol.64.4.785. Mol Pharmacol. 2003. PMID: 14500734 Review. No abstract available.

5

Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.

Chhatriwala M, Ravi RG, Patel RI, Boyer JL, Jacobson KA, Harden TK. Chhatriwala M, et al. Among authors: harden tk. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43. doi: 10.1124/jpet.104.068650. Epub 2004 Sep 2. J Pharmacol Exp Ther. 2004. PMID: 15345752 Free PMC article.

6

UDP is a competitive antagonist at the human P2Y14 receptor.

Fricks IP, Maddileti S, Carter RL, Lazarowski ER, Nicholas RA, Jacobson KA, Harden TK. Fricks IP, et al. Among authors: harden tk. J Pharmacol Exp Ther. 2008 May;325(2):588-94. doi: 10.1124/jpet.108.136309. Epub 2008 Feb 5. J Pharmacol Exp Ther. 2008. PMID: 18252808 Free PMC article.

7

Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.

Fricks IP, Carter RL, Lazarowski ER, Harden TK. Fricks IP, et al. Among authors: harden tk. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8. doi: 10.1124/jpet.109.150730. Epub 2009 Apr 1. J Pharmacol Exp Ther. 2009. PMID: 19339661 Free PMC article.

8

The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.

Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER. Sesma JI, et al. Among authors: harden tk. Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C490-8. doi: 10.1152/ajpcell.00138.2012. Epub 2012 Jun 6. Am J Physiol Cell Physiol. 2012. PMID: 22673622 Free PMC article.

9

A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Barrett MO, Sesma JI, Ball CB, Jayasekara PS, Jacobson KA, Lazarowski ER, Harden TK. Barrett MO, et al. Among authors: harden tk. Mol Pharmacol. 2013 Jul;84(1):41-9. doi: 10.1124/mol.113.085654. Epub 2013 Apr 16. Mol Pharmacol. 2013. PMID: 23592514 Free PMC article.

10

UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.

Lazarowski ER, Harden TK. Lazarowski ER, et al. Among authors: harden tk. Mol Pharmacol. 2015 Jul;88(1):151-60. doi: 10.1124/mol.115.098756. Epub 2015 Mar 31. Mol Pharmacol. 2015. PMID: 25829059 Free PMC article. Review.

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