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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.
Golding SE, Rosenberg E, Valerie N, Hussaini I, Frigerio M, Cockcroft XF, Chong WY, Hummersone M, Rigoreau L, Menear KA, O'Connor MJ, Povirk LF, van Meter T, Valerie K. Golding SE, et al. Among authors: povirk lf. Mol Cancer Ther. 2009 Oct;8(10):2894-902. doi: 10.1158/1535-7163.MCT-09-0519. Epub 2009 Oct 6. Mol Cancer Ther. 2009. PMID: 19808981 Free PMC article.
In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.
Hawkins AJ, Subler MA, Akopiants K, Wiley JL, Taylor SM, Rice AC, Windle JJ, Valerie K, Povirk LF. Hawkins AJ, et al. Among authors: povirk lf. DNA Repair (Amst). 2009 May 1;8(5):654-63. doi: 10.1016/j.dnarep.2008.12.012. Epub 2009 Feb 10. DNA Repair (Amst). 2009. PMID: 19211312 Free PMC article.
Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts.
Akopiants K, Zhou RZ, Mohapatra S, Valerie K, Lees-Miller SP, Lee KJ, Chen DJ, Revy P, de Villartay JP, Povirk LF. Akopiants K, et al. Among authors: povirk lf. Nucleic Acids Res. 2009 Jul;37(12):4055-62. doi: 10.1093/nar/gkp283. Epub 2009 May 6. Nucleic Acids Res. 2009. PMID: 19420065 Free PMC article.
118 results