Gregson SJ - Search Results

1

Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.

Howard PW, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Cooper N, Fang M, Coffils MJ, Klee S, Hartley JA, Thurston DE. Howard PW, et al. Among authors: gregson sj. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6463-6. doi: 10.1016/j.bmcl.2009.09.012. Epub 2009 Sep 9. Bioorg Med Chem Lett. 2009. PMID: 19811912

2

Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.

Gregson SJ, Howard PW, Thurston DE. Gregson SJ, et al. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2277-80. doi: 10.1016/s0960-894x(03)00436-0. Bioorg Med Chem Lett. 2003. PMID: 12824017

3

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE. Gregson SJ, et al. J Med Chem. 2004 Feb 26;47(5):1161-74. doi: 10.1021/jm030897l. J Med Chem. 2004. PMID: 14971896

4

A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents.

Chen Z, Gregson SJ, Howard PW, Thurston DE. Chen Z, et al. Among authors: gregson sj. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1547-9. doi: 10.1016/j.bmcl.2003.12.094. Bioorg Med Chem Lett. 2004. PMID: 15006400

5

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity.

Hartley JA, Hamaguchi A, Coffils M, Martin CR, Suggitt M, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Hartley JM, Pepper C, Lin TT, Fegan C, Thurston DE, Howard PW. Hartley JA, et al. Among authors: gregson sj. Cancer Res. 2010 Sep 1;70(17):6849-58. doi: 10.1158/0008-5472.CAN-10-0790. Epub 2010 Jul 26. Cancer Res. 2010. PMID: 20660714 Free PMC article.

6

DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057.

Hartley JA, Hamaguchi A, Suggitt M, Gregson SJ, Thurston DE, Howard PW. Hartley JA, et al. Among authors: gregson sj. Invest New Drugs. 2012 Jun;30(3):950-8. doi: 10.1007/s10637-011-9647-z. Epub 2011 Mar 8. Invest New Drugs. 2012. PMID: 21384134

7

Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.

Gregson SJ, Masterson LA, Wei B, Pillow TH, Spencer SD, Kang GD, Yu SF, Raab H, Lau J, Li G, Lewis Phillips GD, Gunzner-Toste J, Safina BS, Ohri R, Darwish M, Kozak KR, Dela Cruz-Chuh J, Polson A, Flygare JA, Howard PW. Gregson SJ, et al. J Med Chem. 2017 Dec 14;60(23):9490-9507. doi: 10.1021/acs.jmedchem.7b00736. Epub 2017 Nov 16. J Med Chem. 2017. PMID: 29112410

8

Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers.

Gregson SJ, Barrett AM, Patel NV, Kang GD, Schiavone D, Sult E, Barry CS, Vijayakrishnan B, Adams LR, Masterson LA, D'Hooge F, Snaith M, Harper J, Hartley JA, Howard PW. Gregson SJ, et al. Eur J Med Chem. 2019 Oct 1;179:591-607. doi: 10.1016/j.ejmech.2019.06.044. Epub 2019 Jun 18. Eur J Med Chem. 2019. PMID: 31279293

9

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson SJ, Howard PW, Corcoran KE, Barcella S, Yasin MM, Hurst AA, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1845-7. doi: 10.1016/s0960-894x(00)00351-6. Bioorg Med Chem Lett. 2000. PMID: 10969982

10

Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson SJ, Howard PW, Barcella S, Nakamya A, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1849-51. doi: 10.1016/s0960-894x(00)00350-4. Bioorg Med Chem Lett. 2000. PMID: 10969983

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