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Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels.
Qu C, Ding M, Zhu Y, Lu Y, Du J, Miller M, Tian J, Zhu J, Xu J, Wen M, Er-Bu A, Wang J, Xiao Y, Wu M, McManus OB, Li M, Wu J, Luo HR, Cao Z, Shen B, Wang H, Zhu MX, Hong X. Qu C, et al. Among authors: zhu y, zhu j, zhu mx. J Med Chem. 2017 Jun 8;60(11):4680-4692. doi: 10.1021/acs.jmedchem.7b00304. Epub 2017 Apr 28. J Med Chem. 2017. PMID: 28395140 Free PMC article.
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX. Calcraft PJ, et al. Among authors: zhu y, zhu mx. Nature. 2009 May 28;459(7246):596-600. doi: 10.1038/nature08030. Epub 2009 Apr 22. Nature. 2009. PMID: 19387438 Free PMC article.
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
Miller M, Shi J, Zhu Y, Kustov M, Tian JB, Stevens A, Wu M, Xu J, Long S, Yang P, Zholos AV, Salovich JM, Weaver CD, Hopkins CR, Lindsley CW, McManus O, Li M, Zhu MX. Miller M, et al. Among authors: zhu y, zhu mx. J Biol Chem. 2011 Sep 23;286(38):33436-46. doi: 10.1074/jbc.M111.274167. Epub 2011 Jul 27. J Biol Chem. 2011. PMID: 21795696 Free PMC article.
Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer.
Ding M, Wang H, Qu C, Xu F, Zhu Y, Lv G, Lu Y, Zhou Q, Zhou H, Zeng X, Zhang J, Yan C, Lin J, Luo HR, Deng Z, Xiao Y, Tian J, Zhu MX, Hong X. Ding M, et al. Among authors: zhu y, zhu mx. Cancer Lett. 2018 Sep 28;432:47-55. doi: 10.1016/j.canlet.2018.05.041. Epub 2018 May 31. Cancer Lett. 2018. PMID: 29859875 Free PMC article.
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