Cairns RA - Search Results

1

Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104.

Cairns RA, Bennewith KL, Graves EE, Giaccia AJ, Chang DT, Denko NC. Cairns RA, et al. Clin Cancer Res. 2009 Dec 1;15(23):7170-4. doi: 10.1158/1078-0432.CCR-09-1676. Epub 2009 Nov 17. Clin Cancer Res. 2009. PMID: 19920111 Free PMC article.

2

Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors.

Cairns RA, Kalliomaki T, Hill RP. Cairns RA, et al. Cancer Res. 2001 Dec 15;61(24):8903-8. Cancer Res. 2001. PMID: 11751415

3

Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma.

Cairns RA, Hill RP. Cairns RA, et al. Cancer Res. 2004 Mar 15;64(6):2054-61. doi: 10.1158/0008-5472.can-03-3196. Cancer Res. 2004. PMID: 15026343

4

Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment.

Cairns R, Papandreou I, Denko N. Cairns R, et al. Mol Cancer Res. 2006 Feb;4(2):61-70. doi: 10.1158/1541-7786.MCR-06-0002. Mol Cancer Res. 2006. PMID: 16513837 Review.

5

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. Papandreou I, et al. Among authors: cairns ra. Cell Metab. 2006 Mar;3(3):187-97. doi: 10.1016/j.cmet.2006.01.012. Cell Metab. 2006. PMID: 16517406 Free article.

6

Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy.

Cairns RA, Papandreou I, Sutphin PD, Denko NC. Cairns RA, et al. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9445-50. doi: 10.1073/pnas.0611662104. Epub 2007 May 15. Proc Natl Acad Sci U S A. 2007. PMID: 17517659 Free PMC article.

7

Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.

Chen Y, Cairns R, Papandreou I, Koong A, Denko NC. Chen Y, et al. PLoS One. 2009 Sep 15;4(9):e7033. doi: 10.1371/journal.pone.0007033. PLoS One. 2009. PMID: 19753307 Free PMC article.

8

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.

Agnihotri S, Golbourn B, Huang X, Remke M, Younger S, Cairns RA, Chalil A, Smith CA, Krumholtz SL, Mackenzie D, Rakopoulos P, Ramaswamy V, Taccone MS, Mischel PS, Fuller GN, Hawkins C, Stanford WL, Taylor MD, Zadeh G, Rutka JT. Agnihotri S, et al. Among authors: cairns ra. Cancer Res. 2016 Aug 15;76(16):4708-19. doi: 10.1158/0008-5472.CAN-15-3079. Epub 2016 Jun 20. Cancer Res. 2016. PMID: 27325644

9

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.

Leung E, Cairns RA, Chaudary N, Vellanki RN, Kalliomaki T, Moriyama EH, Mujcic H, Wilson BC, Wouters BG, Hill R, Milosevic M. Leung E, et al. Among authors: cairns ra. BMC Cancer. 2017 Jun 15;17(1):418. doi: 10.1186/s12885-017-3402-6. BMC Cancer. 2017. PMID: 28619042 Free PMC article.

10

A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer.

Han K, Fyles A, Shek T, Croke J, Dhani N, D'Souza D, Lee TY, Chaudary N, Bruce J, Pintilie M, Cairns R, Vines D, Pakbaz S, Jaffray D, Metser U, Rouzbahman M, Milosevic M, Koritzinsky M. Han K, et al. Clin Cancer Res. 2022 Dec 15;28(24):5263-5271. doi: 10.1158/1078-0432.CCR-22-1665. Clin Cancer Res. 2022. PMID: 36037303 Clinical Trial.

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