Davies J - Search Results

1

Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.

Pacorel B, Leung SC, Stachulski AV, Davies J, Vivas L, Lander H, Ward SA, Kaiser M, Brun R, O'Neill PM. Pacorel B, et al. Among authors: davies j. J Med Chem. 2010 Jan 28;53(2):633-40. doi: 10.1021/jm901216v. J Med Chem. 2010. PMID: 19957999

2

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.

Hindley S, Ward SA, Storr RC, Searle NL, Bray PG, Park BK, Davies J, O'Neill PM. Hindley S, et al. Among authors: davies j. J Med Chem. 2002 Feb 28;45(5):1052-63. doi: 10.1021/jm0109816. J Med Chem. 2002. PMID: 11855985

3

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM. Jeyadevan JP, et al. Among authors: davies j. J Med Chem. 2004 Feb 26;47(5):1290-8. doi: 10.1021/jm030974c. J Med Chem. 2004. PMID: 14971909

4

Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.

O'Neill PM, Rawe SL, Borstnik K, Miller A, Ward SA, Bray PG, Davies J, Oh CH, Posner GH. O'Neill PM, et al. Among authors: davies j. Chembiochem. 2005 Nov;6(11):2048-54. doi: 10.1002/cbic.200500048. Chembiochem. 2005. PMID: 16222725

5

Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.

O'Neill PM, Verissimo E, Ward SA, Davies J, Korshin EE, Araujo N, Pugh MD, Cristiano ML, Stocks PA, Bachi MD. O'Neill PM, et al. Among authors: davies j. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2991-5. doi: 10.1016/j.bmcl.2006.02.059. Epub 2006 Mar 9. Bioorg Med Chem Lett. 2006. PMID: 16527481

6

Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology.

Amewu R, Stachulski AV, Berry NG, Ward SA, Davies J, Labat G, Rossignol JF, O'Neill PM. Amewu R, et al. Among authors: davies j. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6124-30. doi: 10.1016/j.bmcl.2006.08.098. Epub 2006 Sep 15. Bioorg Med Chem Lett. 2006. PMID: 16978862

7

Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin.

Amewu R, Stachulski AV, Ward SA, Berry NG, Bray PG, Davies J, Labat G, Vivas L, O'Neill PM. Amewu R, et al. Among authors: davies j. Org Biomol Chem. 2006 Dec 21;4(24):4431-6. doi: 10.1039/b613565j. Epub 2006 Nov 3. Org Biomol Chem. 2006. PMID: 17268634

8

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM. Ellis GL, et al. Among authors: davies j. J Med Chem. 2008 Apr 10;51(7):2170-7. doi: 10.1021/jm701435h. Epub 2008 Mar 15. J Med Chem. 2008. PMID: 18341274

9

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

Jones M, Mercer AE, Stocks PA, La Pensée LJ, Cosstick R, Park BK, Kennedy ME, Piantanida I, Ward SA, Davies J, Bray PG, Rawe SL, Baird J, Charidza T, Janneh O, O'Neill PM. Jones M, et al. Among authors: davies j. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2033-7. doi: 10.1016/j.bmcl.2009.02.028. Epub 2009 Feb 11. Bioorg Med Chem Lett. 2009. PMID: 19249201 Free article.

10

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA. O'Neill PM, et al. Among authors: davies j. J Med Chem. 2009 Apr 9;52(7):1828-44. doi: 10.1021/jm8012757. J Med Chem. 2009. PMID: 19284751 Free article.

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