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Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade.
Markowitz GJ, Ban Y, Tavarez DA, Yoffe L, Podaza E, He Y, Martin MT, Crowley MJP, Sandoval TA, Gao D, Martin ML, Elemento O, Cubillos-Ruiz JR, McGraw TE, Altorki NK, Mittal V. Markowitz GJ, et al. Among authors: cubillos ruiz jr. Res Sq [Preprint]. 2023 Sep 21:rs.3.rs-3356477. doi: 10.21203/rs.3.rs-3356477/v1. Res Sq. 2023. Update in: Nat Immunol. 2024 Oct;25(10):1884-1899. doi: 10.1038/s41590-024-01963-1. PMID: 37790365 Free PMC article. Updated. Preprint.
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer.
Sandoval TA, Salvagno C, Chae CS, Awasthi D, Giovanelli P, Marin Falco M, Hwang SM, Teran-Cabanillas E, Suominen L, Yamazaki T, Kuo HH, Moyer JE, Martin ML, Manohar J, Kim K, Sierra MA, Ramos Y, Tan C, Emmanuelli A, Song M, Morales DK, Zamarin D, Frey MK, Cantillo E, Chapman-Davis E, Holcomb K, Mason CE, Galluzzi L, Ni Zhou Z, Vähärautio A, Cloonan SM, Cubillos-Ruiz JR. Sandoval TA, et al. Among authors: cubillos ruiz jr. Cancer Discov. 2024 Oct 4;14(10):1901-1921. doi: 10.1158/2159-8290.CD-23-1451. Cancer Discov. 2024. PMID: 39073085
Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis.
Awasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, Fernandez Rodriguez JJ, Santagostino SF, Iwawaki T, Romero-Sandoval EA, Crespo MS, Morales DK, Iliev ID, Hohl TM, Cubillos-Ruiz JR. Awasthi D, et al. J Clin Invest. 2023 Sep 1;133(17):e167359. doi: 10.1172/JCI167359. J Clin Invest. 2023. PMID: 37432737 Free PMC article.
PILAR is a novel modulator of human T-cell expansion.
Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG, Engle XA, Rigby WF, Pioli PA, Guyre PM, Conejo-Garcia JR. Huarte E, et al. Blood. 2008 Aug 15;112(4):1259-68. doi: 10.1182/blood-2007-12-130773. Epub 2008 Jun 12. Blood. 2008. PMID: 18550855 Free PMC article.
68 results