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Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis.
Soliman SSM, Baldin C, Gu Y, Singh S, Gebremariam T, Swidergall M, Alqarihi A, Youssef EG, Alkhazraji S, Pikoulas A, Perske C, Venkataramani V, Rich A, Bruno VM, Hotopp JD, Mantis NJ, Edwards JE Jr, Filler SG, Chamilos G, Vitetta ES, Ibrahim AS. Soliman SSM, et al. Among authors: edwards je jr. Nat Microbiol. 2021 Mar;6(3):313-326. doi: 10.1038/s41564-020-00837-0. Epub 2021 Jan 18. Nat Microbiol. 2021. PMID: 33462434 Free PMC article.
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.
Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA Jr, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE Jr, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. Iyer KR, et al. Among authors: edwards je jr. Nat Commun. 2020 Dec 22;11(1):6429. doi: 10.1038/s41467-020-20183-3. Nat Commun. 2020. PMID: 33353950 Free PMC article.
The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection.
Singh S, Uppuluri P, Mamouei Z, Alqarihi A, Elhassan H, French S, Lockhart SR, Chiller T, Edwards JE Jr, Ibrahim AS. Singh S, et al. Among authors: edwards je jr. PLoS Pathog. 2019 Aug 5;15(8):e1007460. doi: 10.1371/journal.ppat.1007460. eCollection 2019 Aug. PLoS Pathog. 2019. PMID: 31381597 Free PMC article.
PCR-Based Approach Targeting Mucorales-Specific Gene Family for Diagnosis of Mucormycosis.
Baldin C, Soliman SSM, Jeon HH, Alkhazraji S, Gebremariam T, Gu Y, Bruno VM, Cornely OA, Leather HL, Sugrue MW, Wingard JR, Stevens DA, Edwards JE Jr, Ibrahim AS. Baldin C, et al. Among authors: edwards je jr. J Clin Microbiol. 2018 Sep 25;56(10):e00746-18. doi: 10.1128/JCM.00746-18. Print 2018 Oct. J Clin Microbiol. 2018. PMID: 30068535 Free PMC article.
The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection.
Uppuluri P, Lin L, Alqarihi A, Luo G, Youssef EG, Alkhazraji S, Yount NY, Ibrahim BA, Bolaris MA, Edwards JE Jr, Swidergall M, Filler SG, Yeaman MR, Ibrahim AS. Uppuluri P, et al. Among authors: edwards je jr. PLoS Pathog. 2018 May 10;14(5):e1007056. doi: 10.1371/journal.ppat.1007056. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29746596 Free PMC article.
A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis-A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial.
Edwards JE Jr, Schwartz MM, Schmidt CS, Sobel JD, Nyirjesy P, Schodel F, Marchus E, Lizakowski M, DeMontigny EA, Hoeg J, Holmberg T, Cooke MT, Hoover K, Edwards L, Jacobs M, Sussman S, Augenbraun M, Drusano M, Yeaman MR, Ibrahim AS, Filler SG, Hennessey JP Jr. Edwards JE Jr, et al. Clin Infect Dis. 2018 Jun 1;66(12):1928-1936. doi: 10.1093/cid/ciy185. Clin Infect Dis. 2018. PMID: 29697768 Free PMC article. Clinical Trial.
154 results