Baker JR - Search Results

1

Protein modification, bioconjugation, and disulfide bridging using bromomaleimides.

Smith ME, Schumacher FF, Ryan CP, Tedaldi LM, Papaioannou D, Waksman G, Caddick S, Baker JR. Smith ME, et al. Among authors: baker jr. J Am Chem Soc. 2010 Feb 17;132(6):1960-5. doi: 10.1021/ja908610s. J Am Chem Soc. 2010. PMID: 20092331 Free PMC article.

2

An efficient synthesis of epoxydiynes and a key fragment of neocarzinostatin chromophore.

Baker JR, Thominet O, Britton H, Caddick S. Baker JR, et al. Org Lett. 2007 Jan 4;9(1):45-8. doi: 10.1021/ol062461g. Org Lett. 2007. PMID: 17192081

3

Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic.

Baker JR, Woolfson DN, Muskett FW, Stoneman RG, Urbaniak MD, Caddick S. Baker JR, et al. Chembiochem. 2007 May 7;8(7):704-17. doi: 10.1002/cbic.200600534. Chembiochem. 2007. PMID: 17451164

4

Synthetic strategies to epoxydiynes and a key synthon of the neocarzinostatin chromophore.

Thominet O, Baker JR, Britton H, Etheridge ZC, Soscia MG, Caddick S. Thominet O, et al. Among authors: baker jr. Org Biomol Chem. 2007 Nov 21;5(22):3703-12. doi: 10.1039/b711196g. Epub 2007 Oct 3. Org Biomol Chem. 2007. PMID: 17972001

5

In situ reduction in photocycloadditions: a method to prevent secondary photoreactions.

Tedaldi LM, Baker JR. Tedaldi LM, et al. Among authors: baker jr. Org Lett. 2009 Feb 19;11(4):811-4. doi: 10.1021/ol8026494. Org Lett. 2009. PMID: 19161262

6

Bromomaleimides: new reagents for the selective and reversible modification of cysteine.

Tedaldi LM, Smith ME, Nathani RI, Baker JR. Tedaldi LM, et al. Among authors: baker jr. Chem Commun (Camb). 2009 Nov 21;(43):6583-5. doi: 10.1039/b915136b. Epub 2009 Sep 16. Chem Commun (Camb). 2009. PMID: 19865657

7

An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity.

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S. Baker JR, et al. Chem Commun (Camb). 2010 Jun 14;46(22):3953-4. doi: 10.1039/c0cc00142b. Epub 2010 Apr 30. Chem Commun (Camb). 2010. PMID: 20431838

8

In situ maleimide bridging of disulfides and a new approach to protein PEGylation.

Schumacher FF, Nobles M, Ryan CP, Smith ME, Tinker A, Caddick S, Baker JR. Schumacher FF, et al. Among authors: baker jr. Bioconjug Chem. 2011 Feb 16;22(2):132-6. doi: 10.1021/bc1004685. Epub 2011 Jan 27. Bioconjug Chem. 2011. PMID: 21271715 Free PMC article.

9

The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists.

Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A, Baker JR. Hothersall JD, et al. Among authors: baker jr. Br J Pharmacol. 2011 Sep;164(2):317-31. doi: 10.1111/j.1476-5381.2011.01269.x. Br J Pharmacol. 2011. PMID: 21323900 Free PMC article.

10

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis.

Ryan CP, Smith ME, Schumacher FF, Grohmann D, Papaioannou D, Waksman G, Werner F, Baker JR, Caddick S. Ryan CP, et al. Among authors: baker jr. Chem Commun (Camb). 2011 May 21;47(19):5452-4. doi: 10.1039/c1cc11114k. Epub 2011 Apr 5. Chem Commun (Camb). 2011. PMID: 21465057 Free PMC article.

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