Smith ME - Search Results

1

Protein modification, bioconjugation, and disulfide bridging using bromomaleimides.

Smith ME, Schumacher FF, Ryan CP, Tedaldi LM, Papaioannou D, Waksman G, Caddick S, Baker JR. Smith ME, et al. J Am Chem Soc. 2010 Feb 17;132(6):1960-5. doi: 10.1021/ja908610s. J Am Chem Soc. 2010. PMID: 20092331 Free PMC article.

2

Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'.

Schumacher FF, Sanchania VA, Tolner B, Wright ZV, Ryan CP, Smith ME, Ward JM, Caddick S, Kay CW, Aeppli G, Chester KA, Baker JR. Schumacher FF, et al. Among authors: smith me. Sci Rep. 2013;3:1525. doi: 10.1038/srep01525. Sci Rep. 2013. PMID: 23519366 Free PMC article.

3

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging.

Schumacher FF, Nunes JP, Maruani A, Chudasama V, Smith ME, Chester KA, Baker JR, Caddick S. Schumacher FF, et al. Among authors: smith me. Org Biomol Chem. 2014 Oct 7;12(37):7261-9. doi: 10.1039/c4ob01550a. Org Biomol Chem. 2014. PMID: 25103319 Free PMC article.

4

Bromomaleimides: new reagents for the selective and reversible modification of cysteine.

Tedaldi LM, Smith ME, Nathani RI, Baker JR. Tedaldi LM, et al. Among authors: smith me. Chem Commun (Camb). 2009 Nov 21;(43):6583-5. doi: 10.1039/b915136b. Epub 2009 Sep 16. Chem Commun (Camb). 2009. PMID: 19865657

5

In situ maleimide bridging of disulfides and a new approach to protein PEGylation.

Schumacher FF, Nobles M, Ryan CP, Smith ME, Tinker A, Caddick S, Baker JR. Schumacher FF, et al. Among authors: smith me. Bioconjug Chem. 2011 Feb 16;22(2):132-6. doi: 10.1021/bc1004685. Epub 2011 Jan 27. Bioconjug Chem. 2011. PMID: 21271715 Free PMC article.

6

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis.

Ryan CP, Smith ME, Schumacher FF, Grohmann D, Papaioannou D, Waksman G, Werner F, Baker JR, Caddick S. Ryan CP, et al. Among authors: smith me. Chem Commun (Camb). 2011 May 21;47(19):5452-4. doi: 10.1039/c1cc11114k. Epub 2011 Apr 5. Chem Commun (Camb). 2011. PMID: 21465057 Free PMC article.

7

Bromopyridazinedione-mediated protein and peptide bioconjugation.

Chudasama V, Smith ME, Schumacher FF, Papaioannou D, Waksman G, Baker JR, Caddick S. Chudasama V, et al. Among authors: smith me. Chem Commun (Camb). 2011 Aug 21;47(31):8781-3. doi: 10.1039/c1cc12807h. Epub 2011 Jul 7. Chem Commun (Camb). 2011. PMID: 21738916 Free PMC article.

8

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.

Castañeda L, Maruani A, Schumacher FF, Miranda E, Chudasama V, Chester KA, Baker JR, Smith ME, Caddick S. Castañeda L, et al. Among authors: smith me. Chem Commun (Camb). 2013 Sep 25;49(74):8187-9. doi: 10.1039/c3cc45220d. Chem Commun (Camb). 2013. PMID: 23929130 Free PMC article.

9

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.

Castañeda L, Wright ZV, Marculescu C, Tran TM, Chudasama V, Maruani A, Hull EA, Nunes JP, Fitzmaurice RJ, Smith ME, Jones LH, Caddick S, Baker JR. Castañeda L, et al. Among authors: smith me. Tetrahedron Lett. 2013 Jul 3;54(27):3493-3495. doi: 10.1016/j.tetlet.2013.04.088. Tetrahedron Lett. 2013. PMID: 24058217 Free PMC article.

10

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents.

Youziel J, Akhbar AR, Aziz Q, Smith ME, Caddick S, Tinker A, Baker JR. Youziel J, et al. Among authors: smith me. Org Biomol Chem. 2014 Jan 28;12(4):557-60. doi: 10.1039/c3ob42141d. Org Biomol Chem. 2014. PMID: 24297212

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