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c-mip impairs podocyte proximal signaling and induces heavy proteinuria.
Zhang SY, Kamal M, Dahan K, Pawlak A, Ory V, Desvaux D, Audard V, Candelier M, BenMohamed F, Matignon M, Christov C, Decrouy X, Bernard V, Mangiapan G, Lang P, Guellaën G, Ronco P, Sahali D. Zhang SY, et al. Among authors: pawlak a. Sci Signal. 2010 May 18;3(122):ra39. doi: 10.1126/scisignal.2000678. Sci Signal. 2010. PMID: 20484117 Free PMC article.
c-mip down-regulates NF-κB activity and promotes apoptosis in podocytes.
Ory V, Fan Q, Hamdaoui N, Zhang SY, Desvaux D, Audard V, Candelier M, Noel LH, Lang P, Guellaën G, Pawlak A, Sahali D. Ory V, et al. Among authors: pawlak a. Am J Pathol. 2012 Jun;180(6):2284-92. doi: 10.1016/j.ajpath.2012.02.008. Epub 2012 Apr 14. Am J Pathol. 2012. PMID: 22507836 Free article.
Upregulation of c-mip is closely related to podocyte dysfunction in membranous nephropathy.
Sendeyo K, Audard V, Zhang SY, Fan Q, Bouachi K, Ollero M, Rucker-Martin C, Gouadon E, Desvaux D, Bridoux F, Guellaën G, Ronco P, Lang P, Pawlak A, Sahali D. Sendeyo K, et al. Among authors: pawlak a. Kidney Int. 2013 Mar;83(3):414-25. doi: 10.1038/ki.2012.426. Epub 2013 Jan 9. Kidney Int. 2013. PMID: 23302718 Free PMC article.
411 results