Karlström H - Search Results

1

gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.

Frånberg J, Karlström H, Winblad B, Tjernberg LO, Frykman S. Frånberg J, et al. Among authors: karlstrom h. PLoS One. 2010 Mar 19;5(3):e9772. doi: 10.1371/journal.pone.0009772. PLoS One. 2010. PMID: 20333303 Free PMC article.

2

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J. Bergman A, et al. Among authors: karlstrom h. Exp Cell Res. 2003 Jul 1;287(1):1-9. doi: 10.1016/s0014-4827(03)00117-4. Exp Cell Res. 2003. PMID: 12799176

3

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.

Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Laudon H, et al. Among authors: karlstrom h. J Neurochem. 2004 Apr;89(1):44-53. doi: 10.1046/j.1471-4159.2003.02298.x. J Neurochem. 2004. PMID: 15030388 Free article.

4

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.

Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J. Laudon H, et al. Among authors: karlstrom h. J Biol Chem. 2004 Jun 4;279(23):23925-32. doi: 10.1074/jbc.M401277200. Epub 2004 Mar 29. J Biol Chem. 2004. PMID: 15051718 Free article.

5

Presenilin dependence of phospholipase C and protein kinase C signaling.

Dehvari N, Cedazo-Minguez A, Isacsson O, Nilsson T, Winblad B, Karlström H, Benedikz E, Cowburn RF. Dehvari N, et al. Among authors: karlstrom h. J Neurochem. 2007 Aug;102(3):848-57. doi: 10.1111/j.1471-4159.2007.04571.x. Epub 2007 Apr 16. J Neurochem. 2007. PMID: 17437536 Free article.

6

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H. Wanngren J, et al. Among authors: karlstrom h. J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27. J Biol Chem. 2010. PMID: 20106965 Free PMC article.

7

γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.

Hedskog L, Petersen CA, Svensson AI, Welander H, Tjernberg LO, Karlström H, Ankarcrona M. Hedskog L, et al. Among authors: karlstrom h. J Cell Mol Med. 2011 Oct;15(10):2150-63. doi: 10.1111/j.1582-4934.2010.01208.x. J Cell Mol Med. 2011. PMID: 21054783 Free PMC article.

8

Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.

Frånberg J, Svensson AI, Winblad B, Karlström H, Frykman S. Frånberg J, et al. Among authors: karlstrom h. Biochem Biophys Res Commun. 2011 Jan 7;404(1):564-8. doi: 10.1016/j.bbrc.2010.12.029. Epub 2010 Dec 10. Biochem Biophys Res Commun. 2011. PMID: 21146496

9

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.

Pamrén A, Wanngren J, Tjernberg LO, Winblad B, Bhat R, Näslund J, Karlström H. Pamrén A, et al. Among authors: karlstrom h. J Biol Chem. 2011 Sep 9;286(36):31153-8. doi: 10.1074/jbc.C111.235267. Epub 2011 Jul 18. J Biol Chem. 2011. PMID: 21768095 Free PMC article.

10

Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.

Wanngren J, Ottervald J, Parpal S, Portelius E, Strömberg K, Borgegård T, Klintenberg R, Juréus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlström H. Wanngren J, et al. Among authors: karlstrom h. J Biol Chem. 2012 Sep 21;287(39):32640-50. doi: 10.1074/jbc.M112.376541. Epub 2012 Jul 31. J Biol Chem. 2012. PMID: 22851182 Free PMC article.

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