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26,461 results

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Page 1
Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology.
Schmidt A, Kimmel DB, Bai C, Scafonas A, Rutledge S, Vogel RL, McElwee-Witmer S, Chen F, Nantermet PV, Kasparcova V, Leu CT, Zhang HZ, Duggan ME, Gentile MA, Hodor P, Pennypacker B, Masarachia P, Opas EE, Adamski SA, Cusick TE, Wang J, Mitchell HJ, Kim Y, Prueksaritanont T, Perkins JJ, Meissner RS, Hartman GD, Freedman LP, Harada S, Ray WJ. Schmidt A, et al. Among authors: chen f. J Biol Chem. 2010 May 28;285(22):17054-64. doi: 10.1074/jbc.M109.099002. Epub 2010 Mar 31. J Biol Chem. 2010. PMID: 20356837 Free PMC article.
The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.
Powzaniuk M, McElwee-Witmer S, Vogel RL, Hayami T, Rutledge SJ, Chen F, Harada S, Schmidt A, Rodan GA, Freedman LP, Bai C. Powzaniuk M, et al. Among authors: chen f. Mol Endocrinol. 2004 Aug;18(8):2011-23. doi: 10.1210/me.2004-0065. Epub 2004 May 6. Mol Endocrinol. 2004. PMID: 15131260
Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs).
Mitchell HJ, Dankulich WP, Hartman GD, Prueksaritanont T, Schmidt A, Vogel RL, Bai C, McElwee-Witmer S, Zhang HZ, Chen F, Leu CT, Kimmel DB, Ray WJ, Nantermet P, Gentile MA, Duggan ME, Meissner RS. Mitchell HJ, et al. Among authors: chen f. J Med Chem. 2009 Aug 13;52(15):4578-81. doi: 10.1021/jm900880r. J Med Chem. 2009. PMID: 19606870
Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands.
Schmidt A, Harada SI, Kimmel DB, Bai C, Chen F, Rutledge SJ, Vogel RL, Scafonas A, Gentile MA, Nantermet PV, McElwee-Witmer S, Pennypacker B, Masarachia P, Sahoo SP, Kim Y, Meissner RS, Hartman GD, Duggan ME, Rodan GA, Towler DA, Ray WJ. Schmidt A, et al. Among authors: chen f. J Biol Chem. 2009 Dec 25;284(52):36367-36376. doi: 10.1074/jbc.M109.049734. Epub 2009 Oct 21. J Biol Chem. 2009. PMID: 19846549 Free PMC article.
Direct agonist/antagonist functions of dehydroepiandrosterone.
Chen F, Knecht K, Birzin E, Fisher J, Wilkinson H, Mojena M, Moreno CT, Schmidt A, Harada S, Freedman LP, Reszka AA. Chen F, et al. Endocrinology. 2005 Nov;146(11):4568-76. doi: 10.1210/en.2005-0368. Epub 2005 Jun 30. Endocrinology. 2005. PMID: 15994348
Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.
Lipfert L, Fisher JE, Wei N, Scafonas A, Su Q, Yudkovitz J, Chen F, Warrier S, Birzin ET, Kim S, Chen HY, Tan Q, Schmidt A, Dininno F, Rohrer SP, Hammond ML, Rodan GA, Freedman LP, Reszka AA. Lipfert L, et al. Among authors: chen hy, chen f. Mol Endocrinol. 2006 Mar;20(3):516-33. doi: 10.1210/me.2005-0190. Epub 2005 Oct 13. Mol Endocrinol. 2006. PMID: 16223974
Androstene-3,5-dienes as ER-beta selective SERMs.
Blizzard TA, Gude C, Morgan JD 2nd, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Mosley RT, Holmes MA, Rohrer SP, Hammond ML. Blizzard TA, et al. Among authors: chen f. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6295-8. doi: 10.1016/j.bmcl.2007.09.001. Epub 2007 Sep 7. Bioorg Med Chem Lett. 2007. PMID: 17890084
Bridged androstenediol analogs as ER-beta selective SERMs.
Blizzard TA, Gude C, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Holmes MA, Rohrer SP, Hammond ML. Blizzard TA, et al. Among authors: chen f. Bioorg Med Chem Lett. 2007 May 15;17(10):2944-8. doi: 10.1016/j.bmcl.2006.12.053. Epub 2006 Dec 21. Bioorg Med Chem Lett. 2007. PMID: 17448656
Androstenediol analogs as ER-beta-selective SERMs.
Blizzard TA, Gude C, Morgan JD 2nd, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Mosley RT, Holmes MA, Sharma N, Fitzgerald PM, Rohrer SP, Hammond ML. Blizzard TA, et al. Among authors: chen f. Bioorg Med Chem Lett. 2006 Feb 15;16(4):834-8. doi: 10.1016/j.bmcl.2005.11.014. Epub 2005 Nov 23. Bioorg Med Chem Lett. 2006. PMID: 16309907
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