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Characterization of HKI-272 covalent binding to human serum albumin.
Wang J, Li-Chan XX, Atherton J, Deng L, Espina R, Yu L, Horwatt P, Ross S, Lockhead S, Ahmad S, Chandrasekaran A, Oganesian A, Scatina J, Mutlib A, Talaat R. Wang J, et al. Among authors: talaat r. Drug Metab Dispos. 2010 Jul;38(7):1083-93. doi: 10.1124/dmd.110.032292. Epub 2010 Apr 16. Drug Metab Dispos. 2010. PMID: 20400660
Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.
Vishwanathan K, Babalola K, Wang J, Espina R, Yu L, Adedoyin A, Talaat R, Mutlib A, Scatina J. Vishwanathan K, et al. Among authors: talaat r. Chem Res Toxicol. 2009 Feb;22(2):311-22. doi: 10.1021/tx8003328. Chem Res Toxicol. 2009. PMID: 19067650
Metabolism of intravenous methylnaltrexone in mice, rats, dogs, and humans.
Chandrasekaran A, Tong Z, Li H, Erve JC, DeMaio W, Goljer I, McConnell O, Rotshteyn Y, Hultin T, Talaat R, Scatina J. Chandrasekaran A, et al. Among authors: talaat r. Drug Metab Dispos. 2010 Apr;38(4):606-16. doi: 10.1124/dmd.109.031179. Epub 2010 Jan 6. Drug Metab Dispos. 2010. PMID: 20053817 Clinical Trial.
113 results