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Sphingosine kinase 1 is a relevant molecular target in gastric cancer.
Fuereder T, Hoeflmayer D, Jaeger-Lansky A, Rasin-Streden D, Strommer S, Fisker N, Hansen BJ, Crevenna R, Wacheck V. Fuereder T, et al. Among authors: jaeger lansky a. Anticancer Drugs. 2011 Mar;22(3):245-52. doi: 10.1097/cad.0b013e328340bd95. Anticancer Drugs. 2011. PMID: 21360847
Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake.
Fuereder T, Wanek T, Pflegerl P, Jaeger-Lansky A, Hoeflmayer D, Strommer S, Kuntner C, Wrba F, Werzowa J, Hejna M, Müller M, Langer O, Wacheck V. Fuereder T, et al. Among authors: jaeger lansky a. Clin Cancer Res. 2011 Aug 15;17(16):5322-32. doi: 10.1158/1078-0432.CCR-10-1659. Epub 2011 Jun 28. Clin Cancer Res. 2011. PMID: 21712451