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Structure-activity relationships of fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyloxime (ABP688) derivatives and the discovery of a high affinity analogue as a potential candidate for imaging metabotropic glutamate recepors subtype 5 (mGluR5) with positron emission tomography (PET).
Baumann CA, Mu L, Johannsen S, Honer M, Schubiger PA, Ametamey SM. Baumann CA, et al. Among authors: ametamey sm. J Med Chem. 2010 May 27;53(10):4009-17. doi: 10.1021/jm901850k. J Med Chem. 2010. PMID: 20411954
Molecular imaging with PET.
Ametamey SM, Honer M, Schubiger PA. Ametamey SM, et al. Chem Rev. 2008 May;108(5):1501-16. doi: 10.1021/cr0782426. Epub 2008 Apr 22. Chem Rev. 2008. PMID: 18426240 Review. No abstract available.
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