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Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys.
Vugmeyster Y, Allen S, Szklut P, Bree A, Ryan M, Ma M, Spaulding V, Young D, Guay H, Bloom L, Leach MW, O'Toole M, Adkins K. Vugmeyster Y, et al. Among authors: ryan m. J Transl Med. 2010 Apr 26;8:41. doi: 10.1186/1479-5876-8-41. J Transl Med. 2010. PMID: 20420683 Free PMC article.
Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody.
Guo Y, Hill AA, Ramsey RC, Immermann FW, Corcoran C, Young D, Lavallie ER, Ryan M, Bechard T, Pfeifer R, Warner G, Bologna M, Bloom L, O'Toole M. Guo Y, et al. Among authors: ryan m. J Transl Med. 2010 May 26;8:50. doi: 10.1186/1479-5876-8-50. J Transl Med. 2010. PMID: 20504348 Free PMC article.
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.
Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. Rankin AL, et al. Among authors: ryan m. J Immunol. 2012 Feb 15;188(4):1656-67. doi: 10.4049/jimmunol.1003871. Epub 2012 Jan 9. J Immunol. 2012. PMID: 22231702 Free PMC article.
Identification of type-II inhibitors using kinase structures.
Lovering F, McDonald J, Whitlock GA, Glossop PA, Phillips C, Bent A, Sabnis Y, Ryan M, Fitz L, Lee J, Chang JS, Han S, Kurumbail R, Thorarensen A. Lovering F, et al. Among authors: ryan m. Chem Biol Drug Des. 2012 Nov;80(5):657-64. doi: 10.1111/j.1747-0285.2012.01443.x. Epub 2012 Sep 3. Chem Biol Drug Des. 2012. PMID: 22759374
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality.
Marchlik E, Thakker P, Carlson T, Jiang Z, Ryan M, Marusic S, Goutagny N, Kuang W, Askew GR, Roberts V, Benoit S, Zhou T, Ling V, Pfeifer R, Stedman N, Fitzgerald KA, Lin LL, Hall JP. Marchlik E, et al. Among authors: ryan m. J Leukoc Biol. 2010 Dec;88(6):1171-80. doi: 10.1189/jlb.0210071. Epub 2010 Jul 22. J Leukoc Biol. 2010. PMID: 20651301
4,882 results