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Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek S, Bergqvist S, Smeal T. Murray BW, et al. Among authors: karlicek s. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. doi: 10.1073/pnas.0911863107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439741 Free PMC article.
Comparative analyses of a small molecule/enzyme interaction by multiple users of Biacore technology.
Cannon MJ, Papalia GA, Navratilova I, Fisher RJ, Roberts LR, Worthy KM, Stephen AG, Marchesini GR, Collins EJ, Casper D, Qiu H, Satpaev D, Liparoto SF, Rice DA, Gorshkova II, Darling RJ, Bennett DB, Sekar M, Hommema E, Liang AM, Day ES, Inman J, Karlicek SM, Ullrich SJ, Hodges D, Chu T, Sullivan E, Simpson J, Rafique A, Luginbühl B, Westin SN, Bynum M, Cachia P, Li YJ, Kao D, Neurauter A, Wong M, Swanson M, Myszka DG. Cannon MJ, et al. Among authors: karlicek sm. Anal Biochem. 2004 Jul 1;330(1):98-113. doi: 10.1016/j.ab.2004.02.027. Anal Biochem. 2004. PMID: 15183767