Westwick JK - Search Results

1

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.

Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek S, Bergqvist S, Smeal T. Murray BW, et al. Among authors: westwick jk. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. doi: 10.1073/pnas.0911863107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439741 Free PMC article.

2

Improving drug discovery with contextual assays and cellular systems analysis.

Westwick JK, Lamerdin JE. Westwick JK, et al. Methods Mol Biol. 2011;756:61-73. doi: 10.1007/978-1-61779-160-4_3. Methods Mol Biol. 2011. PMID: 21870220 Review.

3

Measuring drug action in the cellular context using protein-fragment complementation assays.

Yu H, West M, Keon BH, Bilter GK, Owens S, Lamerdin J, Westwick JK. Yu H, et al. Among authors: westwick jk. Assay Drug Dev Technol. 2003 Dec;1(6):811-22. doi: 10.1089/154065803772613444. Assay Drug Dev Technol. 2003. PMID: 15090227

4

Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase.

Ennis BW, Fultz KE, Smith KA, Westwick JK, Zhu D, Boluro-Ajayi M, Bilter GK, Stein B. Ennis BW, et al. Among authors: westwick jk. J Pharmacol Exp Ther. 2005 Apr;313(1):325-32. doi: 10.1124/jpet.104.078873. Epub 2004 Dec 30. J Pharmacol Exp Ther. 2005. PMID: 15626722

5

Identifying off-target effects and hidden phenotypes of drugs in human cells.

MacDonald ML, Lamerdin J, Owens S, Keon BH, Bilter GK, Shang Z, Huang Z, Yu H, Dias J, Minami T, Michnick SW, Westwick JK. MacDonald ML, et al. Among authors: westwick jk. Nat Chem Biol. 2006 Jun;2(6):329-37. doi: 10.1038/nchembio790. Epub 2006 May 7. Nat Chem Biol. 2006. PMID: 16680159

6

Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays.

Stossi F, Bolt MJ, Ashcroft FJ, Lamerdin JE, Melnick JS, Powell RT, Dandekar RD, Mancini MG, Walker CL, Westwick JK, Mancini MA. Stossi F, et al. Among authors: westwick jk. Chem Biol. 2014 Jun 19;21(6):743-53. doi: 10.1016/j.chembiol.2014.03.013. Epub 2014 May 22. Chem Biol. 2014. PMID: 24856822 Free PMC article.

7

Therapeutic modulation of inflammatory gene transcription by kinase inhibitors.

Alton G, Schwamborn K, Satoh Y, Westwick JK. Alton G, et al. Among authors: westwick jk. Expert Opin Biol Ther. 2002 Aug;2(6):621-32. doi: 10.1517/14712598.2.6.621. Expert Opin Biol Ther. 2002. PMID: 12171506 Review.

8

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.

Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. Westwick JK, et al. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6030-4. doi: 10.1073/pnas.91.13.6030. Proc Natl Acad Sci U S A. 1994. PMID: 8016110 Free PMC article.

9

JNK mediates hepatic ischemia reperfusion injury.

Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA. Uehara T, et al. Among authors: westwick jk. J Hepatol. 2005 Jun;42(6):850-9. doi: 10.1016/j.jhep.2005.01.030. Epub 2005 Apr 7. J Hepatol. 2005. PMID: 15885356

10

Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation.

Pruitt K, Pruitt WM, Bilter GK, Westwick JK, Der CJ. Pruitt K, et al. Among authors: westwick jk. J Biol Chem. 2002 Aug 30;277(35):31808-17. doi: 10.1074/jbc.M203964200. Epub 2002 Jun 24. J Biol Chem. 2002. PMID: 12082106 Free article.

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