Richard JP - Search Results

1

Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.

Toth K, Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Toth K, et al. Among authors: richard jp. J Am Chem Soc. 2010 May 26;132(20):7018-24. doi: 10.1021/ja102408k. J Am Chem Soc. 2010. PMID: 20441167 Free PMC article.

2

Structure-reactivity relationships for beta-galactosidase (Escherichia coli, lac Z). 3. Evidence that Glu-461 participates in Brønsted acid-base catalysis of beta-D-galactopyranosyl group transfer.

Richard JP, Huber RE, Lin S, Heo C, Amyes TL. Richard JP, et al. Biochemistry. 1996 Sep 24;35(38):12377-86. doi: 10.1021/bi961028j. Biochemistry. 1996. PMID: 8823173

3

Structure-reactivity relationships for beta-galactosidase (Escherichia coli, lac Z). 4. Mechanism for reaction of nucleophiles with the galactosyl-enzyme intermediates of E461G and E461Q beta-galactosidases.

Richard JP, Huber RE, Heo C, Amyes TL, Lin S. Richard JP, et al. Biochemistry. 1996 Sep 24;35(38):12387-401. doi: 10.1021/bi961029b. Biochemistry. 1996. PMID: 8823174

4

Dynamics for reaction of an ion pair in aqueous solution: reactivity of carboxylate anions in bimolecular carbocation-nucleophile addition and unimolecular ion pair collapse.

Tsuji Y, Mori T, Richard JP, Amyes TL, Fujio M, Tsuno Y. Tsuji Y, et al. Among authors: richard jp. Org Lett. 2001 Apr 19;3(8):1237-40. doi: 10.1021/ol015706s. Org Lett. 2001. PMID: 11348203

5

Effect of an E461G mutation of beta-galactosidase (Escherichia coli, lac Z) on pL rate profiles and solvent deuterium isotope effects.

Richard JP, Huber RE, McCall DA. Richard JP, et al. Bioorg Chem. 2001 Jun;29(3):146-55. doi: 10.1006/bioo.2001.1206. Bioorg Chem. 2001. PMID: 11437390

6

What is the stabilizing interaction with nucleophilic solvents in the transition state for solvolysis of tertiary derivatives: nucleophilic solvent participation or nucleophilic solvation?

Richard JP, Toteva MM, Amyes TL. Richard JP, et al. Org Lett. 2001 Jul 12;3(14):2225-8. doi: 10.1021/ol016103j. Org Lett. 2001. PMID: 11440585

7

Mechanistic imperatives for aldose-ketose isomerization in water: specific, general base- and metal ion-catalyzed isomerization of glyceraldehyde with proton and hydride transfer.

Nagorski RW, Richard JP. Nagorski RW, et al. Among authors: richard jp. J Am Chem Soc. 2001 Feb 7;123(5):794-802. doi: 10.1021/ja003433a. J Am Chem Soc. 2001. PMID: 11456612

8

Glycine enolates: the large effect of iminium ion formation on alpha-amino carbon acidity.

Rios A, Crugeiras J, Amyes TL, Richard JP. Rios A, et al. Among authors: richard jp. J Am Chem Soc. 2001 Aug 15;123(32):7949-50. doi: 10.1021/ja016250c. J Am Chem Soc. 2001. PMID: 11493086 No abstract available.

9

Contribution of phosphate intrinsic binding energy to the enzymatic rate acceleration for triosephosphate isomerase.

Amyes TL, O'Donoghue AC, Richard JP. Amyes TL, et al. Among authors: richard jp. J Am Chem Soc. 2001 Nov 14;123(45):11325-6. doi: 10.1021/ja016754a. J Am Chem Soc. 2001. PMID: 11697989 No abstract available.

10

Proton transfer at carbon.

Richard JP, Amyes TL. Richard JP, et al. Curr Opin Chem Biol. 2001 Dec;5(6):626-33. doi: 10.1016/s1367-5931(01)00258-7. Curr Opin Chem Biol. 2001. PMID: 11738171 Review.

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