Wood BM - Search Results

1

Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.

Toth K, Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Toth K, et al. Among authors: wood bm. J Am Chem Soc. 2010 May 26;132(20):7018-24. doi: 10.1021/ja102408k. J Am Chem Soc. 2010. PMID: 20441167 Free PMC article.

2

An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms.

Toth K, Amyes TL, Wood BM, Chan KK, Gerlt JA, Richard JP. Toth K, et al. Among authors: wood bm. Biochemistry. 2009 Aug 25;48(33):8006-13. doi: 10.1021/bi901064k. Biochemistry. 2009. PMID: 19618917 Free PMC article.

3

Activation of R235A mutant orotidine 5'-monophosphate decarboxylase by the guanidinium cation: effective molarity of the cationic side chain of Arg-235.

Barnett SA, Amyes TL, Wood BM, Gerlt JA, Richard JP. Barnett SA, et al. Among authors: wood bm. Biochemistry. 2010 Feb 9;49(5):824-6. doi: 10.1021/bi902174q. Biochemistry. 2010. PMID: 20050635 Free PMC article.

4

Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions.

Amyes TL, Ming SA, Goldman LM, Wood BM, Desai BJ, Gerlt JA, Richard JP. Amyes TL, et al. Among authors: wood bm. Biochemistry. 2012 Jun 12;51(23):4630-2. doi: 10.1021/bi300585e. Epub 2012 May 31. Biochemistry. 2012. PMID: 22620855 Free PMC article.

5

Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent.

Tsang WY, Wood BM, Wong FM, Wu W, Gerlt JA, Amyes TL, Richard JP. Tsang WY, et al. Among authors: wood bm. J Am Chem Soc. 2012 Sep 5;134(35):14580-94. doi: 10.1021/ja3058474. Epub 2012 Aug 21. J Am Chem Soc. 2012. PMID: 22812629 Free PMC article.

6

Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.

Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Desai BJ, et al. Among authors: wood bm. Biochemistry. 2012 Oct 30;51(43):8665-78. doi: 10.1021/bi301188k. Epub 2012 Oct 17. Biochemistry. 2012. PMID: 23030629 Free PMC article.

7

Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate.

Toth K, Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Toth K, et al. Among authors: wood bm. J Am Chem Soc. 2007 Oct 31;129(43):12946-7. doi: 10.1021/ja076222f. Epub 2007 Oct 5. J Am Chem Soc. 2007. PMID: 17918849 Free PMC article. No abstract available.

8

Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP.

Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Amyes TL, et al. Among authors: wood bm. J Am Chem Soc. 2008 Feb 6;130(5):1574-5. doi: 10.1021/ja710384t. Epub 2008 Jan 11. J Am Chem Soc. 2008. PMID: 18186641 Free PMC article.

9

Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.

Barnett SA, Amyes TL, Wood BM, Gerlt JA, Richard JP. Barnett SA, et al. Among authors: wood bm. Biochemistry. 2008 Jul 29;47(30):7785-7. doi: 10.1021/bi800939k. Epub 2008 Jul 4. Biochemistry. 2008. PMID: 18598058 Free PMC article.

10

Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants.

Wood BM, Chan KK, Amyes TL, Richard JP, Gerlt JA. Wood BM, et al. Biochemistry. 2009 Jun 23;48(24):5510-7. doi: 10.1021/bi9006226. Biochemistry. 2009. PMID: 19435313 Free PMC article.

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