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Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.
Lin TH, Hegen M, Quadros E, Nickerson-Nutter CL, Appell KC, Cole AG, Shao Y, Tam S, Ohlmeyer M, Wang B, Goodwin DG, Kimble EF, Quintero J, Gao M, Symanowicz P, Wrocklage C, Lussier J, Schelling SH, Hewet AG, Xuan D, Krykbaev R, Togias J, Xu X, Harrison R, Mansour T, Collins M, Clark JD, Webb ML, Seidl KJ. Lin TH, et al. Among authors: webb ml. Arthritis Rheum. 2010 Aug;62(8):2283-93. doi: 10.1002/art.27536. Arthritis Rheum. 2010. PMID: 20506481 Free article.
2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
Cole AG, Bohnstedt AC, Paradkar V, Kingsbury C, Quintero JG, Park H, Lu Y, You M, Neagu I, Diller DJ, Letourneau JJ, Shao Y, James RA, Riviello CM, Ho KK, Lin TH, Wang B, Appell KC, Sills M, Quadros E, Kimble EF, Ohlmeyer MH, Webb ML. Cole AG, et al. Among authors: webb ml. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6788-92. doi: 10.1016/j.bmcl.2009.09.080. Epub 2009 Sep 25. Bioorg Med Chem Lett. 2009. PMID: 19836234
Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists.
Merritt JR, Liu J, Quadros E, Morris ML, Liu R, Zhang R, Jacob B, Postelnek J, Hicks CM, Chen W, Kimble EF, Rogers WL, O'Brien L, White N, Desai H, Bansal S, King G, Ohlmeyer MJ, Appell KC, Webb ML. Merritt JR, et al. Among authors: webb ml. J Med Chem. 2009 Mar 12;52(5):1295-301. doi: 10.1021/jm801416q. J Med Chem. 2009. PMID: 19183043
Novel pyrrolidine heterocycles as CCR1 antagonists.
Merritt JR, James R, Paradkar VM, Zhang C, Liu R, Liu J, Jacob B, Chiriac C, Ohlmeyer MJ, Quadros E, Wines P, Postelnek J, Hicks CM, Chen W, Kimble EF, O'Brien L, White N, Desai H, Appell KC, Webb ML. Merritt JR, et al. Among authors: webb ml. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5477-9. doi: 10.1016/j.bmcl.2010.07.082. Epub 2010 Jul 24. Bioorg Med Chem Lett. 2010. PMID: 20708929
Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists.
Letourneau JJ, Riviello CM, Li H, Cole AG, Ho KK, Zanetakos HA, Desai H, Zhao J, Auld DS, Napier SE, Thomson FJ, Goan KA, Morphy JR, Ohlmeyer MH, Webb ML. Letourneau JJ, et al. Among authors: webb ml. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5394-7. doi: 10.1016/j.bmcl.2010.07.118. Epub 2010 Aug 1. Bioorg Med Chem Lett. 2010. PMID: 20719508
Identification and hit-to-lead optimization of a novel class of CB1 antagonists.
Letourneau JJ, Jokiel P, Olson J, Riviello CM, Ho KK, McAleer L, Yang J, Swanson RN, Baker J, Cowley P, Edwards D, Ward N, Ohlmeyer MH, Webb ML. Letourneau JJ, et al. Among authors: webb ml. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5449-53. doi: 10.1016/j.bmcl.2010.07.091. Epub 2010 Jul 25. Bioorg Med Chem Lett. 2010. PMID: 20719511
184 results