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New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening.
Major MB, Roberts BS, Berndt JD, Marine S, Anastas J, Chung N, Ferrer M, Yi X, Stoick-Cooper CL, von Haller PD, Kategaya L, Chien A, Angers S, MacCoss M, Cleary MA, Arthur WT, Moon RT. Major MB, et al. Among authors: roberts bs. Sci Signal. 2008 Nov 11;1(45):ra12. doi: 10.1126/scisignal.2000037. Sci Signal. 2008. PMID: 19001663
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT. James RG, et al. Among authors: roberts bs. Sci Signal. 2009 May 26;2(72):ra25. doi: 10.1126/scisignal.2000230. Sci Signal. 2009. PMID: 19471023 Free PMC article.
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.
Madan B, Walker MP, Young R, Quick L, Orgel KA, Ryan M, Gupta P, Henrich IC, Ferrer M, Marine S, Roberts BS, Arthur WT, Berndt JD, Oliveira AM, Moon RT, Virshup DM, Chou MM, Major MB. Madan B, et al. Among authors: roberts bs. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2945-54. doi: 10.1073/pnas.1605691113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162353 Free PMC article.
An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies.
O'Neil J, Benita Y, Feldman I, Chenard M, Roberts B, Liu Y, Li J, Kral A, Lejnine S, Loboda A, Arthur W, Cristescu R, Haines BB, Winter C, Zhang T, Bloecher A, Shumway SD. O'Neil J, et al. Among authors: roberts b. Mol Cancer Ther. 2016 Jun;15(6):1155-62. doi: 10.1158/1535-7163.MCT-15-0843. Epub 2016 Mar 16. Mol Cancer Ther. 2016. PMID: 26983881
A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors.
Loboda A, Nebozhyn M, Klinghoffer R, Frazier J, Chastain M, Arthur W, Roberts B, Zhang T, Chenard M, Haines B, Andersen J, Nagashima K, Paweletz C, Lynch B, Feldman I, Dai H, Huang P, Watters J. Loboda A, et al. Among authors: roberts b. BMC Med Genomics. 2010 Jun 30;3:26. doi: 10.1186/1755-8794-3-26. BMC Med Genomics. 2010. PMID: 20591134 Free PMC article.
2,398 results