Scott CL - Search Results

1

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.

Campbell KJ, Bath ML, Turner ML, Vandenberg CJ, Bouillet P, Metcalf D, Scott CL, Cory S. Campbell KJ, et al. Among authors: scott cl. Blood. 2010 Oct 28;116(17):3197-207. doi: 10.1182/blood-2010-04-281071. Epub 2010 Jul 14. Blood. 2010. PMID: 20631380 Free PMC article.

2

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival.

Villunger A, Scott C, Bouillet P, Strasser A. Villunger A, et al. Blood. 2003 Mar 15;101(6):2393-400. doi: 10.1182/blood-2002-07-2132. Epub 2002 Nov 14. Blood. 2003. PMID: 12433687 Free article.

3

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

Scott CL, Schuler M, Marsden VS, Egle A, Pellegrini M, Nesic D, Gerondakis S, Nutt SL, Green DR, Strasser A. Scott CL, et al. J Cell Biol. 2004 Jan 5;164(1):89-96. doi: 10.1083/jcb.200310041. J Cell Biol. 2004. PMID: 14709542 Free PMC article.

4

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC. van Delft MF, et al. Among authors: scott cl. Cancer Cell. 2006 Nov;10(5):389-99. doi: 10.1016/j.ccr.2006.08.027. Cancer Cell. 2006. PMID: 17097561 Free PMC article.

5

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

Coultas L, Terzano S, Thomas T, Voss A, Reid K, Stanley EG, Scott CL, Bouillet P, Bartlett P, Ham J, Adams JM, Strasser A. Coultas L, et al. Among authors: scott cl. J Cell Sci. 2007 Jun 15;120(Pt 12):2044-52. doi: 10.1242/jcs.002063. Epub 2007 May 29. J Cell Sci. 2007. PMID: 17535852 Free PMC article.

6

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic.

Cragg MS, Jansen ES, Cook M, Harris C, Strasser A, Scott CL. Cragg MS, et al. Among authors: scott cl. J Clin Invest. 2008 Nov;118(11):3651-9. doi: 10.1172/JCI35437. Epub 2008 Oct 23. J Clin Invest. 2008. PMID: 18949058 Free PMC article.

7

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas.

Mason KD, Vandenberg CJ, Scott CL, Wei AH, Cory S, Huang DC, Roberts AW. Mason KD, et al. Among authors: scott cl. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17961-6. doi: 10.1073/pnas.0809957105. Epub 2008 Nov 11. Proc Natl Acad Sci U S A. 2008. PMID: 19004807 Free PMC article.

8

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.

Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL. Michalak EM, et al. Among authors: scott cl. Cell Death Differ. 2009 May;16(5):684-96. doi: 10.1038/cdd.2008.195. Epub 2009 Jan 16. Cell Death Differ. 2009. PMID: 19148184 Free PMC article.

9

The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy.

Ellis L, Bots M, Lindemann RK, Bolden JE, Newbold A, Cluse LA, Scott CL, Strasser A, Atadja P, Lowe SW, Johnstone RW. Ellis L, et al. Among authors: scott cl. Blood. 2009 Jul 9;114(2):380-93. doi: 10.1182/blood-2008-10-182758. Epub 2009 Apr 21. Blood. 2009. PMID: 19383971 Free PMC article.

10

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

McKenzie MD, Jamieson E, Jansen ES, Scott CL, Huang DC, Bouillet P, Allison J, Kay TW, Strasser A, Thomas HE. McKenzie MD, et al. Among authors: scott cl. Diabetes. 2010 Mar;59(3):644-52. doi: 10.2337/db09-1151. Epub 2009 Dec 3. Diabetes. 2010. PMID: 19959756 Free PMC article.

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