Johnston PA - Search Results

1

Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.

Dudgeon DD, Shinde S, Hua Y, Shun TY, Lazo JS, Strock CJ, Giuliano KA, Taylor DL, Johnston PA, Johnston PA. Dudgeon DD, et al. Among authors: johnston pa. J Biomol Screen. 2010 Aug;15(7):766-82. doi: 10.1177/1087057110375304. Epub 2010 Jul 16. J Biomol Screen. 2010. PMID: 20639499

2

Cellular platforms for HTS: three case studies.

Johnston PA, Johnston PA. Johnston PA, et al. Drug Discov Today. 2002 Mar 15;7(6):353-63. doi: 10.1016/s1359-6446(01)02140-7. Drug Discov Today. 2002. PMID: 11893544 Review.

3

Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors.

Williams RG, Kandasamy R, Nickischer D, Trask OJ Jr, Laethem C, Johnston PA, Johnston PA. Williams RG, et al. Among authors: johnston pa. Methods Enzymol. 2006;414:364-89. doi: 10.1016/S0076-6879(06)14021-5. Methods Enzymol. 2006. PMID: 17110203

4

Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform.

Trask OJ Jr, Baker A, Williams RG, Nickischer D, Kandasamy R, Laethem C, Johnston PA, Johnston PA. Trask OJ Jr, et al. Among authors: johnston pa. Methods Enzymol. 2006;414:419-39. doi: 10.1016/S0076-6879(06)14023-9. Methods Enzymol. 2006. PMID: 17110205

5

Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors.

Arnold DM, Foster C, Huryn DM, Lazo JS, Johnston PA, Wipf P. Arnold DM, et al. Among authors: johnston pa. Chem Biol Drug Des. 2007 Jan;69(1):23-30. doi: 10.1111/j.1747-0285.2007.00474.x. Chem Biol Drug Des. 2007. PMID: 17313454

6

Development and optimization of high-throughput in vitro protein phosphatase screening assays.

Tierno MB, Johnston PA, Foster C, Skoko JJ, Shinde SN, Shun TY, Lazo JS. Tierno MB, et al. Among authors: johnston pa. Nat Protoc. 2007;2(5):1134-44. doi: 10.1038/nprot.2007.155. Nat Protoc. 2007. PMID: 17546004

7

Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors.

Johnston PA, Foster CA, Shun TY, Skoko JJ, Shinde S, Wipf P, Lazo JS. Johnston PA, et al. Assay Drug Dev Technol. 2007 Jun;5(3):319-32. doi: 10.1089/adt.2007.066. Assay Drug Dev Technol. 2007. PMID: 17638532

8

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.

Johnston PA, Phillips J, Shun TY, Shinde S, Lazo JS, Huryn DM, Myers MC, Ratnikov BI, Smith JW, Su Y, Dahl R, Cosford ND, Shiryaev SA, Strongin AY. Johnston PA, et al. Assay Drug Dev Technol. 2007 Dec;5(6):737-50. doi: 10.1089/adt.2007.101. Assay Drug Dev Technol. 2007. PMID: 18181690

9

Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents.

Johnston PA, Soares KM, Shinde SN, Foster CA, Shun TY, Takyi HK, Wipf P, Lazo JS. Johnston PA, et al. Assay Drug Dev Technol. 2008 Aug;6(4):505-18. doi: 10.1089/adt.2008.151. Assay Drug Dev Technol. 2008. PMID: 18699726 Free PMC article.

10

Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

Keinan S, Paquette WD, Skoko JJ, Beratan DN, Yang W, Shinde S, Johnston PA, Lazo JS, Wipf P. Keinan S, et al. Among authors: johnston pa. Org Biomol Chem. 2008 Sep 21;6(18):3256-63. doi: 10.1039/b806712k. Epub 2008 Jul 15. Org Biomol Chem. 2008. PMID: 18802630 Free PMC article.

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