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Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology.
Larocque D, Sanderson NS, Bergeron J, Curtin JF, Girton J, Wibowo M, Bondale N, Kroeger KM, Yang J, Lacayo LM, Reyes KC, Farrokhi C, Pechnick RN, Castro MG, Lowenstein PR. Larocque D, et al. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14443-8. doi: 10.1073/pnas.0913496107. Epub 2010 Jul 26. Proc Natl Acad Sci U S A. 2010. PMID: 20660723 Free PMC article.
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.
Barcia C, Jimenez-Dalmaroni M, Kroeger KM, Puntel M, Rapaport AJ, Larocque D, King GD, Johnson SA, Liu C, Xiong W, Candolfi M, Mondkar S, Ng P, Palmer D, Castro MG, Lowenstein PR. Barcia C, et al. Among authors: larocque d. Mol Ther. 2007 Dec;15(12):2154-63. doi: 10.1038/sj.mt.6300305. Epub 2007 Sep 25. Mol Ther. 2007. PMID: 17895861 Free PMC article.
Immunology and the central nervous system.
Barcia C, Curtin J, Zirger J, Larocque D. Barcia C, et al. Among authors: larocque d. Clin Dev Immunol. 2013;2013:512684. doi: 10.1155/2013/512684. Epub 2013 Dec 31. Clin Dev Immunol. 2013. PMID: 24489576 Free PMC article. No abstract available.
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology.
Michaud JP, Hallé M, Lampron A, Thériault P, Préfontaine P, Filali M, Tribout-Jover P, Lanteigne AM, Jodoin R, Cluff C, Brichard V, Palmantier R, Pilorget A, Larocque D, Rivest S. Michaud JP, et al. Among authors: larocque d. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1941-6. doi: 10.1073/pnas.1215165110. Epub 2013 Jan 15. Proc Natl Acad Sci U S A. 2013. PMID: 23322736 Free PMC article.
Methods to monitor monocytes-mediated amyloid-beta uptake and phagocytosis in the context of adjuvanted immunotherapies.
Hallé M, Tribout-Jover P, Lanteigne AM, Boulais J, St-Jean JR, Jodoin R, Girouard MP, Constantin F, Migneault A, Renaud F, Didierlaurent AM, Mallett CP, Burkhart D, Pilorget A, Palmantier R, Larocque D. Hallé M, et al. Among authors: larocque d. J Immunol Methods. 2015 Sep;424:64-79. doi: 10.1016/j.jim.2015.05.002. Epub 2015 May 19. J Immunol Methods. 2015. PMID: 26002154 Free article.
Evaluation of novel synthetic TLR7/8 agonists as vaccine adjuvants.
Smith AJ, Li Y, Bazin HG, St-Jean JR, Larocque D, Evans JT, Baldridge JR. Smith AJ, et al. Among authors: larocque d. Vaccine. 2016 Aug 5;34(36):4304-12. doi: 10.1016/j.vaccine.2016.06.080. Epub 2016 Jul 9. Vaccine. 2016. PMID: 27402566 Free PMC article.
AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity.
Didierlaurent AM, Morel S, Lockman L, Giannini SL, Bisteau M, Carlsen H, Kielland A, Vosters O, Vanderheyde N, Schiavetti F, Larocque D, Van Mechelen M, Garçon N. Didierlaurent AM, et al. Among authors: larocque d. J Immunol. 2009 Nov 15;183(10):6186-97. doi: 10.4049/jimmunol.0901474. Epub 2009 Oct 28. J Immunol. 2009. PMID: 19864596
45 results