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A single amino acid mutation attenuates rundown of voltage-gated calcium channels.
Zhen XG, Xie C, Yamada Y, Zhang Y, Doyle C, Yang J. Zhen XG, et al. Among authors: yang j. FEBS Lett. 2006 Oct 16;580(24):5733-8. doi: 10.1016/j.febslet.2006.09.027. Epub 2006 Sep 22. FEBS Lett. 2006. PMID: 17010345 Free PMC article.
In P/Q-type channels, the attenuation of rundown is accompanied by an increased apparent affinity for phosphatidylinositol-4,5-bisphosphate, which has been shown to be critical for maintaining Ca(2+) channel activity [L. Wu, C.S. Bauer, X.-G. Zhen, C. Xie, J. Yang, …
In P/Q-type channels, the attenuation of rundown is accompanied by an increased apparent affinity for phosphatidylinositol-4,5-bisphosphate, …
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