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An introduction to maximum-likelihood methods in cryo-EM.
Sigworth FJ, Doerschuk PC, Carazo JM, Scheres SH. Sigworth FJ, et al. Among authors: scheres sh. Methods Enzymol. 2010;482:263-94. doi: 10.1016/S0076-6879(10)82011-7. Methods Enzymol. 2010. PMID: 20888965 Free PMC article.
Disease-specific tau filaments assemble via polymorphic intermediates.
Lövestam S, Li D, Wagstaff JL, Kotecha A, Kimanius D, McLaughlin SH, Murzin AG, Freund SMV, Goedert M, Scheres SHW. Lövestam S, et al. Among authors: scheres shw. Nature. 2024 Jan;625(7993):119-125. doi: 10.1038/s41586-023-06788-w. Epub 2023 Nov 29. Nature. 2024. PMID: 38030728 Free PMC article.
Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. Qi C, et al. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2306767120. doi: 10.1073/pnas.2306767120. Epub 2023 Dec 15. Proc Natl Acad Sci U S A. 2023. PMID: 38100415 Free PMC article.
Insights into the molecular architecture of the 26S proteasome.
Nickell S, Beck F, Scheres SH, Korinek A, Förster F, Lasker K, Mihalache O, Sun N, Nagy I, Sali A, Plitzko JM, Carazo JM, Mann M, Baumeister W. Nickell S, et al. Among authors: scheres sh. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11943-7. doi: 10.1073/pnas.0905081106. Epub 2009 Jul 6. Proc Natl Acad Sci U S A. 2009. PMID: 19581588 Free PMC article.
145 results