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Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR. Bayascas JR, et al. Among authors: van diepen ja, van aalten dm. Mol Cell Biol. 2008 May;28(10):3258-72. doi: 10.1128/MCB.02032-07. Epub 2008 Mar 17. Mol Cell Biol. 2008. PMID: 18347057 Free PMC article.
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, van den Berg SA, Rensen PC, Voshol PJ, Fantuzzi G, Hijmans A, Kersten S, Müller M, van den Berg WB, van Rooijen N, Wabitsch M, Kullberg BJ, van der Meer JW, Kanneganti T, Tack CJ, Netea MG. Stienstra R, et al. Among authors: van tits b, van rooijen n, van diepen ja, van den berg sa, van der meer jw, van den berg wb. Cell Metab. 2010 Dec 1;12(6):593-605. doi: 10.1016/j.cmet.2010.11.011. Cell Metab. 2010. PMID: 21109192 Free PMC article.
Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice.
Declercq J, Kumar A, Van Diepen JA, Vroegrijk IO, Gysemans C, Di Pietro C, Voshol PJ, Mathieu C, Ectors N, Van de Ven WJ, Verfaillie CM. Declercq J, et al. Among authors: van diepen ja, van de ven wj. Diabetes. 2010 Aug;59(8):1957-65. doi: 10.2337/db09-1446. Epub 2010 Jun 3. Diabetes. 2010. PMID: 20522588 Free PMC article.
Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice.
Wong MC, van Diepen JA, Hu L, Guigas B, de Boer HC, van Puijvelde GH, Kuiper J, van Zonneveld AJ, Shoelson SE, Voshol PJ, Romijn JA, Havekes LM, Tamsma JT, Rensen PC, Hiemstra PS, Berbée JF. Wong MC, et al. Among authors: van diepen ja, van zonneveld aj, van puijvelde gh. Atherosclerosis. 2012 Feb;220(2):362-8. doi: 10.1016/j.atherosclerosis.2011.06.055. Epub 2011 Jul 12. Atherosclerosis. 2012. PMID: 21798539 Free PMC article.
Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice.
Vroegrijk IO, van Diepen JA, van den Berg S, Westbroek I, Keizer H, Gambelli L, Hontecillas R, Bassaganya-Riera J, Zondag GC, Romijn JA, Havekes LM, Voshol PJ. Vroegrijk IO, et al. Among authors: van diepen ja, van den berg s. Food Chem Toxicol. 2011 Jun;49(6):1426-30. doi: 10.1016/j.fct.2011.03.037. Epub 2011 Mar 31. Food Chem Toxicol. 2011. PMID: 21440024
55 results