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Page 1
Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.
Li X, Zhang YK, Liu Y, Zhang S, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Liu L, Bu W, Kazmierski WM, Wright LL, Smith GK, Jarvest RL, Duan M, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Ni ZJ, Zou W, Wright J. Li X, et al. Among authors: creech k. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7493-7. doi: 10.1016/j.bmcl.2010.10.007. Epub 2010 Oct 30. Bioorg Med Chem Lett. 2010. PMID: 21041080
Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.
Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L, Kazmierski WM, Duan M, Grimes RM, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Ni ZJ, Zou W, Wright J. Li X, et al. Among authors: creech k. Bioorg Med Chem Lett. 2011 Apr 1;21(7):2048-54. doi: 10.1016/j.bmcl.2011.02.006. Epub 2011 Feb 23. Bioorg Med Chem Lett. 2011. PMID: 21353550
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A, Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L. Kazmierski WM, et al. Among authors: creech k. J Med Chem. 2012 Apr 12;55(7):3021-6. doi: 10.1021/jm201278q. Epub 2012 Apr 3. J Med Chem. 2012. PMID: 22471376
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.
Li X, Liu Y, Zhang YK, Plattner JJ, Baker SJ, Bu W, Liu L, Zhou Y, Ding CZ, Zhang S, Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A. Li X, et al. Among authors: creech k. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7351-6. doi: 10.1016/j.bmcl.2012.10.075. Epub 2012 Oct 22. Bioorg Med Chem Lett. 2012. PMID: 23142614
Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.
Li X, Zhang YK, Liu Y, Ding CZ, Zhou Y, Li Q, Plattner JJ, Baker SJ, Zhang S, Kazmierski WM, Wright LL, Smith GK, Grimes RM, Crosby RM, Creech KL, Carballo LH, Slater MJ, Jarvest RL, Thommes P, Hubbard JA, Convery MA, Nassau PM, McDowell W, Skarzynski TJ, Qian X, Fan D, Liao L, Ni ZJ, Pennicott LE, Zou W, Wright J. Li X, et al. Among authors: creech kl. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5695-700. doi: 10.1016/j.bmcl.2010.08.022. Epub 2010 Aug 10. Bioorg Med Chem Lett. 2010. PMID: 20801653
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.
Chong PY, Shotwell JB, Miller J, Price DJ, Maynard A, Voitenleitner C, Mathis A, Williams S, Pouliot JJ, Creech K, Wang F, Fang J, Zhang H, Tai VW, Turner E, Kahler KM, Crosby R, Peat AJ. Chong PY, et al. Among authors: creech k. J Med Chem. 2019 Apr 11;62(7):3254-3267. doi: 10.1021/acs.jmedchem.8b01719. Epub 2019 Mar 7. J Med Chem. 2019. PMID: 30763090 Free PMC article.
Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization.
Shotwell JB, Baskaran S, Chong P, Creech KL, Crosby RM, Dickson H, Fang J, Garrido D, Mathis A, Maung J, Parks DJ, Pouliot JJ, Price DJ, Rai R, Seal JW 3rd, Schmitz U, Tai VW, Thomson M, Xie M, Xiong ZZ, Peat AJ. Shotwell JB, et al. ACS Med Chem Lett. 2012 May 24;3(7):565-9. doi: 10.1021/ml300090x. eCollection 2012 Jul 12. ACS Med Chem Lett. 2012. PMID: 24900511 Free PMC article.
In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor.
Voitenleitner C, Crosby R, Walker J, Remlinger K, Vamathevan J, Wang A, You S, Johnson J 3rd, Woldu E, Van Horn S, Horton J, Creech K, Shotwell JB, Hong Z, Hamatake R. Voitenleitner C, et al. Among authors: creech k. Antimicrob Agents Chemother. 2013 Nov;57(11):5216-24. doi: 10.1128/AAC.00874-13. Epub 2013 Aug 12. Antimicrob Agents Chemother. 2013. PMID: 23939896 Free PMC article.
37 results