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Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity.
Tang M, Zhang X, Li Y, Guan Y, Ai X, Szeto C, Nakayama H, Zhang H, Ge S, Molkentin JD, Houser SR, Chen X. Tang M, et al. Among authors: szeto c. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H519-28. doi: 10.1152/ajpheart.00265.2010. Epub 2010 Jun 11. Am J Physiol Heart Circ Physiol. 2010. PMID: 20543081 Free PMC article.
Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.
Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X. Zhang X, et al. Among authors: szeto c. Basic Res Cardiol. 2016 Jan;111(1):4. doi: 10.1007/s00395-015-0523-4. Epub 2015 Nov 26. Basic Res Cardiol. 2016. PMID: 26611208 Free PMC article.
Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.
Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X. Zhang X, et al. Among authors: szeto c. Circ Res. 2013 Feb 1;112(3):498-509. doi: 10.1161/CIRCRESAHA.112.273896. Epub 2012 Oct 25. Circ Res. 2013. PMID: 23104882 Free PMC article.
Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart.
Zhang Y, Wang WE, Zhang X, Li Y, Chen B, Liu C, Ai X, Zhang X, Tian Y, Zhang C, Tang M, Szeto C, Hua X, Xie M, Zeng C, Wu Y, Zhou L, Zhu W, Yu D, Houser SR, Chen X. Zhang Y, et al. Among authors: szeto c. Circ Res. 2019 Jun 7;124(12):1760-1777. doi: 10.1161/CIRCRESAHA.118.313417. Epub 2019 Apr 15. Circ Res. 2019. PMID: 30982412
Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong GS, Zhou J, Liu JB, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O'Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R, Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ. Wong GS, et al. Among authors: szeto c. Nat Med. 2018 Jul;24(7):968-977. doi: 10.1038/s41591-018-0022-x. Epub 2018 May 28. Nat Med. 2018. PMID: 29808010 Free PMC article.
Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong GS, Zhou J, Bin Liu J, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O'Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R, Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ. Wong GS, et al. Among authors: szeto c. Nat Med. 2018 Oct;24(10):1627. doi: 10.1038/s41591-018-0168-6. Nat Med. 2018. PMID: 30093730
645 results