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PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter.
Chen JJ, Sun YL, Tiwari AK, Xiao ZJ, Sodani K, Yang DH, Vispute SG, Jiang WQ, Chen SD, Chen ZS. Chen JJ, et al. Among authors: sodani k. Cancer Sci. 2012 Aug;103(8):1531-7. doi: 10.1111/j.1349-7006.2012.02328.x. Epub 2012 Jul 6. Cancer Sci. 2012. PMID: 22578167 Free PMC article.
OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance.
Kuang YH, Patel JP, Sodani K, Wu CP, Liao LQ, Patel A, Tiwari AK, Dai CL, Chen X, Fu LW, Ambudkar SV, Korlipara VL, Chen ZS. Kuang YH, et al. Among authors: sodani k. Biochem Pharmacol. 2012 Sep 15;84(6):766-74. doi: 10.1016/j.bcp.2012.06.019. Epub 2012 Jun 28. Biochem Pharmacol. 2012. PMID: 22750060 Free PMC article.
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